Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia.
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia.
Molecules. 2019 Mar 4;24(5):899. doi: 10.3390/molecules24050899.
There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research.
人们越来越意识到富含水果和蔬菜的饮食对人类健康的重要性。癌症干细胞（CSC）的特征是一群具有自我更新、增殖或凋亡异常调节的癌细胞，导致癌症进展、侵袭、转移形成和治疗耐药。植物化学物质的抗癌作用也针对 CSC。在这里，我们提供了一个针对 CSC 的饮食植物化学物质的综合综述。此外，我们评估和总结了关于饮食植物化学物质对各种恶性肿瘤 CSC 的临床前和临床研究。饮食植物化学物质对 CSC 有显著影响，可应用于癌症的预防和治疗。然而，植物来源化合物的抗癌作用在临床研究中尚未得到充分研究。
