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Commentary: Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration-A Mass Spectrometry Imaging Study of the Perfused Rat Liver.述评：在治疗浓度下，二甲双胍不改变乳酸诱导的葡萄糖输出——灌注大鼠肝脏的质谱成像研究
Front Pharmacol. 2019 Feb 19;10:90. doi: 10.3389/fphar.2019.00090. eCollection 2019.
2
Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver.治疗浓度的二甲双胍不改变乳酸诱导的葡萄糖输出——灌注大鼠肝脏的质谱成像研究
Front Pharmacol. 2018 Feb 22;9:141. doi: 10.3389/fphar.2018.00141. eCollection 2018.
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Molecular action of metformin in hepatocytes: an updated insight.二甲双胍在肝细胞中的分子作用：最新见解
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Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver.二甲双胍对灌注大鼠肝脏中乳酸摄取和糖异生的影响。
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Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.链脲佐菌素诱导的糖尿病中柠檬酸循环活性和糖异生的改变以及二甲双胍的作用
Diabetes. 1999 Jun;48(6):1251-7. doi: 10.2337/diabetes.48.6.1251.
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Effects of metformin on glucose metabolism of perfused rat livers.二甲双胍对灌流大鼠肝脏糖代谢的影响。
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Effects of arterial-portal glucose difference on gluconeogenesis from lactate in the isolated bivascular-perfused rat liver.动脉-门静脉葡萄糖差异对离体双血管灌注大鼠肝脏中乳酸糖异生的影响。
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Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration.底物诱导的糖异生未能增加正常人的总体葡萄糖生成。证明了肝脏的自动调节且血浆葡萄糖浓度无变化。
J Clin Invest. 1990 Aug;86(2):489-97. doi: 10.1172/JCI114735.
10
Cellular metabolite distribution and the control of gluconeogenesis in the perfused isolated rat liver.灌注离体大鼠肝脏中的细胞代谢物分布与糖异生的调控
Pflugers Arch. 1976 Mar 11;362(1):49-54. doi: 10.1007/BF00588680.

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Metformin Effects on SHIP2, AMPKs and Gut Microbiota: Recent Updates on Pharmacology.二甲双胍对SHIP2、AMPK和肠道微生物群的影响：药理学最新进展
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Mitochondrial complex I inhibition triggers NAD-independent glucose oxidation via successive NADPH formation, "futile" fatty acid cycling, and FADH oxidation.线粒体复合物 I 抑制通过连续的 NADPH 形成、“无效”脂肪酸循环和 FADH 氧化触发 NAD 独立的葡萄糖氧化。
Geroscience. 2024 Aug;46(4):3635-3658. doi: 10.1007/s11357-023-01059-y. Epub 2024 Jan 25.
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Metformin: update on mechanisms of action and repurposing potential.二甲双胍：作用机制及再利用潜力的最新研究进展。
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The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective.二甲双胍在糖异生和 AMPK 激活方面的作用机制：代谢物视角。
Int J Mol Sci. 2020 May 3;21(9):3240. doi: 10.3390/ijms21093240.

本文引用的文献

1
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.低剂量二甲双胍导致肝细胞中线粒体 NADH/NAD 氧化还原状态更加氧化，并通过一种与氧化还原无关的机制抑制糖异生。
J Biol Chem. 2019 Feb 22;294(8):2839-2853. doi: 10.1074/jbc.RA118.006670. Epub 2018 Dec 27.
2
Metformin Affects Heme Function as a Possible Mechanism of Action.二甲双胍影响血红素功能，这可能是其作用机制之一。
G3 (Bethesda). 2019 Feb 7;9(2):513-522. doi: 10.1534/g3.118.200803.
3
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.二甲双胍通过抑制果糖-1,6-二磷酸酶来减少肝脏葡萄糖的生成。
Nat Med. 2018 Sep;24(9):1395-1406. doi: 10.1038/s41591-018-0159-7. Epub 2018 Aug 27.
4
Metformin as an Anticancer Agent.二甲双胍作为一种抗癌剂。
Trends Pharmacol Sci. 2018 Oct;39(10):867-878. doi: 10.1016/j.tips.2018.07.006. Epub 2018 Aug 24.
5
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.二甲双胍通过体内的氧化还原依赖机制抑制糖异生。
Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23.
6
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.二甲双胍直接靶向 H3K27me3 去甲基化酶 KDM6A/UTX。
Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8.
7
Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver.治疗浓度的二甲双胍不改变乳酸诱导的葡萄糖输出——灌注大鼠肝脏的质谱成像研究
Front Pharmacol. 2018 Feb 22;9:141. doi: 10.3389/fphar.2018.00141. eCollection 2018.
8
Metformin does not affect postabsorptive hepatic free fatty acid uptake, oxidation or resecretion in humans: A 3-month placebo-controlled clinical trial in patients with type 2 diabetes and healthy controls.二甲双胍并不影响人类餐后肝游离脂肪酸的摄取、氧化或再分泌：一项为期 3 个月的 2 型糖尿病患者和健康对照的安慰剂对照临床试验。
Diabetes Obes Metab. 2018 Jun;20(6):1435-1444. doi: 10.1111/dom.13244. Epub 2018 Mar 4.
9
A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study.二甲双胍在健康志愿者中的非线性药代动力学-药效学关系：一项开放标签、平行组、随机临床试验。
PLoS One. 2018 Jan 17;13(1):e0191258. doi: 10.1371/journal.pone.0191258. eCollection 2018.
10
Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.双胍类药物对线粒体活性氧产生的多效作用。
Oxid Med Cell Longev. 2017;2017:7038603. doi: 10.1155/2017/7038603. Epub 2017 Aug 9.

Commentary: Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration-A Mass Spectrometry Imaging Study of the Perfused Rat Liver.

作者信息

Glossmann Hartmut H, Lutz Oliver M D

机构信息

Institute for Biochemical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Austrian Drug Screening Institute GmbH, Innsbruck, Austria.

出版信息

Front Pharmacol. 2019 Feb 19;10:90. doi: 10.3389/fphar.2019.00090. eCollection 2019.

DOI:10.3389/fphar.2019.00090
PMID:30837871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6389785/
Abstract
摘要