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从沙漠到医学:骆驼基因组学与治疗产品综述

From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products.

作者信息

Ali Amanat, Baby Bincy, Vijayan Ranjit

机构信息

Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.

出版信息

Front Genet. 2019 Feb 19;10:17. doi: 10.3389/fgene.2019.00017. eCollection 2019.

Abstract

Camels have an important role in the lives of human beings, especially in arid regions, due to their multipurpose role and unique ability to adapt to harsh conditions. In spite of its enormous economic, cultural, and biological importance, the camel genome has not been widely studied. The size of camel genome is roughly 2.38 GB, containing over 20,000 genes. The unusual genetic makeup of the camel is the main reason behind its ability to survive under extreme environmental conditions. The camel genome harbors several unique variations which are being investigated for the treatment of several disorders. Various natural products from camels have also been tested and prescribed as adjunct therapy to control the progression of ailments. Interestingly, the camel employs unique immunological and molecular mechanisms against pathogenic agents and pathological conditions. Here, we broadly review camel classification, distribution and breed as well as recent progress in the determination of the camel genome, its size, genetic distribution, response to various physiological conditions, immunogenetics and the medicinal potential of camel gene products.

摘要

骆驼在人类生活中扮演着重要角色,尤其是在干旱地区,这得益于它们的多功能性以及适应恶劣环境的独特能力。尽管骆驼具有巨大的经济、文化和生物学重要性,但其基因组尚未得到广泛研究。骆驼基因组大小约为2.38GB,包含超过20000个基因。骆驼不同寻常的基因构成是其能够在极端环境条件下生存的主要原因。骆驼基因组存在一些独特变异,目前正在对这些变异进行研究,以用于治疗多种疾病。骆驼的各种天然产物也已进行测试,并被用作辅助疗法来控制疾病的进展。有趣的是,骆驼针对病原体和病理状况采用独特的免疫和分子机制。在此,我们广泛综述骆驼的分类、分布和品种,以及在骆驼基因组测定、其大小、基因分布、对各种生理条件的反应、免疫遗传学和骆驼基因产物的药用潜力方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5904/6389616/b8e06374e14d/fgene-10-00017-g001.jpg

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