Cp*Co(III)/MPAA催化硫代酰胺导向的二茂铁在温和条件下的对映选择性酰胺化反应
Cp*Co(III)/MPAA-Catalyzed Enantioselective Amidation of Ferrocenes Directed by Thioamides under Mild Conditions.
作者信息
Liu Yan-Hua, Li Peng-Xiang, Yao Qi-Jun, Zhang Zhuo-Zhuo, Huang Dan-Ying, Le Minh Dong, Song Hong, Liu Lei, Shi Bing-Feng
机构信息
Department of Chemistry , Zhejiang University , Hangzhou 310027 , China.
School of Biotechnology and Health Sciences , Wuyi University , Jiangmen 529020 , China.
出版信息
Org Lett. 2019 Mar 15;21(6):1895-1899. doi: 10.1021/acs.orglett.9b00511. Epub 2019 Mar 6.
Cp*Cobalt(III)-catalyzed enantioselective C-H amidation of ferrocenes using monoprotected amino acids (MPAAs) as chiral ligands was developed. The reaction was performed under mild conditions in high yields (up to 97%) with moderate enantioselectivity (up to 77.5:22.5 er), providing a promising strategy to create planar chirality via base-metal-catalyzed enantioselective C-H activation.
开发了使用单保护氨基酸（MPAA）作为手性配体的Cp*钴（III）催化的二茂铁对映选择性C-H酰胺化反应。该反应在温和条件下进行，产率高（高达97%），对映选择性适中（高达77.5:22.5 er），为通过贱金属催化的对映选择性C-H活化产生平面手性提供了一种有前景的策略。
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