阴道毛滴虫感染与晚期前列腺癌风险
Trichomonas vaginalis infection and risk of advanced prostate cancer.
作者信息
Shui Irene M, Kolb Suzanne, Hanson Christi, Sutcliffe Siobhan, Rider Jennifer R, Stanford Janet L
机构信息
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
出版信息
Prostate. 2016 May;76(7):620-3. doi: 10.1002/pros.23153. Epub 2016 Jan 28.
BACKGROUND
The epidemiologic evidence for an association of Trichomonas vaginalis (Tv) with overall prostate cancer is mixed, but some studies suggest Tv may increase risk of more aggressive disease. The aim of this study was to assess whether Tv serostatus is associated with advanced or fatal prostate cancer.
METHODS
A total of 146 men with advanced (metastatic or fatal) prostate cancer and 181 age-matched controls were selected from two prior population-based, case-control studies. Tv serostatus was determined with the same laboratory methods used in previous epidemiologic studies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression to compare Tv serostatus in prostate cancer cases and controls adjusted for potential confounders.
RESULTS
The seroprevalence of Tv in controls was 23%. Tv serostatus was not associated with an increased risk of metastatic or fatal prostate cancer (ORs < 1).
CONCLUSIONS
Our study does not support an increased risk of advanced or fatal prostate cancer in men seropositive for Tv.
背景
关于阴道毛滴虫（Tv）与总体前列腺癌之间关联的流行病学证据不一，但一些研究表明Tv可能会增加患侵袭性更强疾病的风险。本研究的目的是评估Tv血清状态是否与晚期或致命性前列腺癌相关。
方法
从两项先前基于人群的病例对照研究中选取了146例晚期（转移性或致命性）前列腺癌男性患者和181例年龄匹配的对照。采用先前流行病学研究中使用的相同实验室方法确定Tv血清状态。使用多变量逻辑回归计算比值比（OR）和95%置信区间（CI），以比较在调整了潜在混杂因素后前列腺癌病例和对照中的Tv血清状态。
结果
对照中Tv的血清阳性率为23%。Tv血清状态与转移性或致命性前列腺癌风险增加无关（OR<1）。
结论
我们的研究不支持Tv血清阳性男性患晚期或致命性前列腺癌的风险增加。
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