• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

聚 N-异丙基丙烯酰胺水凝胶中普洛色林的异常释放动力学及其在三阴性乳腺癌治疗中的应用。

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer.

机构信息

Department of Mechanical Engineering, Ashesi University, Berekuso, Ghana.

Department of Materials Science and Engineering, African University of Science and Technology, km 10, Airport RD, Federal Capital Territory, Abuja, Nigeria.

出版信息

Sci Rep. 2019 Mar 7;9(1):3862. doi: 10.1038/s41598-019-39578-4.

DOI:10.1038/s41598-019-39578-4
PMID:30846795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6405774/
Abstract

This paper presents the anomalous release kinetics of a cancer drug (prodigiosin) frompoly-n-isopropyl-acrylamide (P(NIPA))-based gels. The release exponents, n, which correspond to the drug release mechanisms, were found to be between 0.41 and 1.40. This is within a range that include Fickian case I (n = 0.45) and non-Fickian diffusion (case II) (n > 0.45) for cylindrical drug-loaded structures. The results, however, suggest that the release exponents, n, correspond mostly to anomalous case II and super case II transport mechanics with sigmoidal characteristics. The drug release kinetics of the P(NIPA)-based hydrogels are well described by bi-dose functions. The observed drug release behavour is related to the porosity of the hydrogels, which can be controlled by cross-linking and copolymerization with acrylamide, which also improves the hydrophilicity of the gels. The paper also presents the effects of cancer drug release on cell survival (%), as well as the cell metabolic activities of treated cells and non-treated cells. The implications of the results are discussed for the development of implantable thermosensitive gels for the controlled release of drugs for localized cancer treatment.

摘要

本文介绍了一种癌症药物（灵菌红素）从聚 N-异丙基丙烯酰胺（P（NIPA））基凝胶中的异常释放动力学。与药物释放机制相对应的释放指数 n 被发现介于 0.41 和 1.40 之间。这是在包括圆柱状载药结构中的菲克第一案例（n = 0.45）和非菲克扩散（案例 II）（n > 0.45）的范围内。然而，结果表明，释放指数 n 主要对应于异常案例 II 和超案例 II 输送力学，具有 S 型特征。P（NIPA）基水凝胶的药物释放动力学很好地用双剂量函数描述。观察到的药物释放行为与水凝胶的孔隙率有关，孔隙率可以通过与丙烯酰胺的交联和共聚来控制，这也提高了凝胶的亲水性。本文还介绍了癌症药物释放对细胞存活率（%）以及处理细胞和未处理细胞的细胞代谢活性的影响。讨论了这些结果对用于局部癌症治疗的药物控释的可植入热敏水凝胶的发展的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/fe6747e75197/41598_2019_39578_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/8cd75becf96f/41598_2019_39578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/ea0b077e3b14/41598_2019_39578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/e8962ead7e5f/41598_2019_39578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/849719994957/41598_2019_39578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/b19466a80f84/41598_2019_39578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/e51b62ef298c/41598_2019_39578_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/cd6f5db8bc61/41598_2019_39578_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/ed10a4e13253/41598_2019_39578_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/fe6747e75197/41598_2019_39578_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/8cd75becf96f/41598_2019_39578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/ea0b077e3b14/41598_2019_39578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/e8962ead7e5f/41598_2019_39578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/849719994957/41598_2019_39578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/b19466a80f84/41598_2019_39578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/e51b62ef298c/41598_2019_39578_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/cd6f5db8bc61/41598_2019_39578_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/ed10a4e13253/41598_2019_39578_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/6405774/fe6747e75197/41598_2019_39578_Fig9_HTML.jpg

相似文献

1
Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer.聚 N-异丙基丙烯酰胺水凝胶中普洛色林的异常释放动力学及其在三阴性乳腺癌治疗中的应用。
Sci Rep. 2019 Mar 7;9(1):3862. doi: 10.1038/s41598-019-39578-4.
2
Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release.从可植入生物医学装置中释放灵菌红素：局部癌症药物释放动力学
Mater Sci Eng C Mater Biol Appl. 2014 Sep;42:734-45. doi: 10.1016/j.msec.2014.06.008. Epub 2014 Jun 19.
3
Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery.聚(N-异丙基丙烯酰胺) P(NIPA)-基水凝胶原位肿瘤药物递送的细菌合成血晶素增容作用。
Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:19-29. doi: 10.1016/j.msec.2015.09.090. Epub 2015 Sep 28.
4
Degradable porous drug-loaded polymer scaffolds for localized cancer drug delivery and breast cell/tissue growth.可降解多孔载药聚合物支架用于局部癌症药物输送和乳腺细胞/组织生长。
Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110794. doi: 10.1016/j.msec.2020.110794. Epub 2020 Mar 2.
5
PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: Effects of particle size on drug release kinetics and cell viability.负载细菌合成灵菌红素的聚乳酸-羟基乙酸共聚物基微粒用于抗癌药物释放：粒径对药物释放动力学和细胞活力的影响
Mater Sci Eng C Mater Biol Appl. 2016 Sep 1;66:51-65. doi: 10.1016/j.msec.2016.04.071. Epub 2016 Apr 21.
6
Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels.分子设计的聚（丙烯酸 - g - 乙二醇）水凝胶的药物传输机制及释放动力学
Biomaterials. 2006 Nov;27(31):5440-51. doi: 10.1016/j.biomaterials.2006.06.011. Epub 2006 Jul 7.
7
Rheological behavior of biodegradable N-succinyl chitosan-g-poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release.可生物降解的 N-琥珀酰壳聚糖-g-聚丙烯酸水凝胶的流变行为及其作为药物载体和茶碱体外释放的应用。
Int J Biol Macromol. 2018 Oct 1;117:454-466. doi: 10.1016/j.ijbiomac.2018.05.182. Epub 2018 May 25.
8
Fluconazole release from hydrogels including acrylamide-acrylic acid-itaconic acid, and their microbiological interactions.氟康唑从包含丙烯酰胺-丙烯酸-衣康酸的水凝胶中的释放及其微生物相互作用。
J Biomater Sci Polym Ed. 2008;19(2):193-205. doi: 10.1163/156856208783432480.
9
A comparative study of the adhesion of biosynthesized gold and conjugated gold/prodigiosin nanoparticles to triple negative breast cancer cells.生物合成金和共轭金/血晶素纳米颗粒对三阴性乳腺癌细胞黏附的比较研究。
J Mater Sci Mater Med. 2017 Aug 17;28(9):143. doi: 10.1007/s10856-017-5943-2.
10
Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties.阴离子型聚合物水凝胶中超扩散纳米运动的证据：PGSE-NMR 数据分析及与药物释放性能的比较。
J Control Release. 2019 Jul 10;305:110-119. doi: 10.1016/j.jconrel.2019.05.027. Epub 2019 May 20.

引用本文的文献

1
Promising Prodiginins Biological Activities.有前景的灵菌红素生物活性。
Chem Biodivers. 2025 Sep;22(9):e202402940. doi: 10.1002/cbdv.202402940. Epub 2025 May 6.
2
Hydrogel Innovations in Biosensing: A New Frontier for Pancreatitis Diagnostics.生物传感中的水凝胶创新：胰腺炎诊断的新前沿。
Bioengineering (Basel). 2025 Mar 3;12(3):254. doi: 10.3390/bioengineering12030254.
3
Comparing the effectiveness of curcumin and papain in wound dresses based on chitosan nanoparticle.基于壳聚糖纳米颗粒比较姜黄素和木瓜蛋白酶在伤口敷料中的有效性。

本文引用的文献

1
Extended pulsated drug release from PLGA-based minirods.基于聚乳酸-羟基乙酸共聚物（PLGA）的微棒实现延长的脉冲式药物释放。
J Mater Sci Mater Med. 2017 Apr;28(4):61. doi: 10.1007/s10856-017-5866-y. Epub 2017 Mar 1.
2
Polymeric composite devices for localized treatment of early-stage breast cancer.用于早期乳腺癌局部治疗的聚合物复合装置。
PLoS One. 2017 Feb 28;12(2):e0172542. doi: 10.1371/journal.pone.0172542. eCollection 2017.
3
PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: Effects of particle size on drug release kinetics and cell viability.
3 Biotech. 2025 Jan;15(1):27. doi: 10.1007/s13205-024-04193-2. Epub 2024 Dec 28.
4
Enzymatically Triggered Drug Release from Microgels Controlled by Glucose Concentration.酶触发的微凝胶药物释放受葡萄糖浓度控制。
ACS Biomater Sci Eng. 2024 Oct 14;10(10):6415-6424. doi: 10.1021/acsbiomaterials.4c01721. Epub 2024 Oct 2.
5
From Synthesis to Solutions: Hydrogels' Impact on the Biomedical Landscape.从合成到解决方案：水凝胶对生物医学领域的影响。
Curr Pharm Biotechnol. 2024 May 20. doi: 10.2174/0113892010294727240502051954.
6
Hydrogel Breakthroughs in Biomedicine: Recent Advances and Implications.水凝胶在生物医学中的突破：最新进展及影响。
Curr Pharm Biotechnol. 2024;25(11):1436-1451. doi: 10.2174/0113892010281021231229100228.
7
Repaglinide-Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box-Behnken Design, Characterization, and In Vivo Evaluation.瑞格列奈固体脂质纳米粒壳聚糖贴片经皮给药：Box-Behnken 设计、表征和体内评价。
Int J Nanomedicine. 2024 Jan 10;19:209-230. doi: 10.2147/IJN.S438564. eCollection 2024.
8
In-vivo studies of targeted and localized cancer drug release from microporous poly-di-methyl-siloxane (PDMS) devices for the treatment of triple negative breast cancer.多微孔聚二甲基硅氧烷（PDMS）装置靶向和局部癌症药物释放的体内研究，用于治疗三阴性乳腺癌。
Sci Rep. 2024 Jan 2;14(1):31. doi: 10.1038/s41598-023-50656-6.
9
Discriminative Dissolution Method Using the Open-Loop Configuration of the USP IV Apparatus to Compare Dissolution Profiles of Metoprolol Tartrate Immediate-Release Tablets: Use of Kinetic Parameters.采用美国药典IV型装置的开环配置比较酒石酸美托洛尔速释片溶出曲线的鉴别溶出方法：动力学参数的应用
Pharmaceutics. 2023 Aug 24;15(9):2191. doi: 10.3390/pharmaceutics15092191.
10
Zeolite Nanoparticles Loaded with 2-Methoxystradiol as a Novel Drug Delivery System for the Prostate Cancer Therapy.载有 2-甲氧基雌二醇的沸石纳米颗粒作为治疗前列腺癌的新型药物传递系统。
Int J Mol Sci. 2023 Jun 30;24(13):10967. doi: 10.3390/ijms241310967.
负载细菌合成灵菌红素的聚乳酸-羟基乙酸共聚物基微粒用于抗癌药物释放：粒径对药物释放动力学和细胞活力的影响
Mater Sci Eng C Mater Biol Appl. 2016 Sep 1;66:51-65. doi: 10.1016/j.msec.2016.04.071. Epub 2016 Apr 21.
4
Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery.聚(N-异丙基丙烯酰胺) P(NIPA)-基水凝胶原位肿瘤药物递送的细菌合成血晶素增容作用。
Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:19-29. doi: 10.1016/j.msec.2015.09.090. Epub 2015 Sep 28.
5
1. Commentary on an exponential model for the analysis of drug delivery: Original research article: a simple equation for description of solute release: I II. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, 1987.1. 药物递送分析指数模型述评：原创研究文章：溶质释放描述的一个简单方程：I II. 平板、球体、圆柱体或圆盘形式的非溶胀装置中的菲克和非菲克释放，1987年。
J Control Release. 2014 Sep 28;190:31-2.
6
Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release.从可植入生物医学装置中释放灵菌红素：局部癌症药物释放动力学
Mater Sci Eng C Mater Biol Appl. 2014 Sep;42:734-45. doi: 10.1016/j.msec.2014.06.008. Epub 2014 Jun 19.
7
Water absorption, retention and the swelling characteristics of cassava starch grafted with polyacrylic acid.木薯淀粉接枝聚丙烯酸的吸水、保水和溶胀特性。
Carbohydr Polym. 2014 Mar 15;103:325-32. doi: 10.1016/j.carbpol.2013.12.056. Epub 2013 Dec 22.
8
Near-infrared-actuated devices for remotely controlled drug delivery.近红外光驱动的远程控制药物输送装置。
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1349-54. doi: 10.1073/pnas.1322651111. Epub 2014 Jan 13.
9
Swelling and diffusion of PNIPA-based gels for localized chemotherapy and hyperthermia.基于 PNIPA 的水凝胶用于局部化疗和热疗的肿胀和扩散。
Mater Sci Eng C Mater Biol Appl. 2012 Jan 1;32(1):24-30. doi: 10.1016/j.msec.2011.09.006. Epub 2011 Sep 16.
10
Kinetic modeling on drug release from controlled drug delivery systems.药物控释系统中药物释放的动力学建模
Acta Pol Pharm. 2010 May-Jun;67(3):217-23.