Kofoed H
Acta Orthop Scand. 1986 Apr;57(2):119-22. doi: 10.3109/17453678609000882.
Arthrosis was induced in the rabbit knee, making it unstable by ligament resection. Acidity and hypercapnia were found in the synovial fluid of the arthrotic knees, whereas oxygen partial pressure was normal. In arthrotic subchondral bone the intraosseous pressure and oxygen partial pressure were increased; intraosseous phlebography showed venous congestion. Histologic specimens showed increased subchondral bone formation, loss of cartilage and total depletion of glycosaminoglycans. The synovial membrane was hyperplastic and fibrosis was found in the underlying tissue. We suggest that changes in environmental haemodynamics and metabolism, although secondary in nature, may play an important role in the arthrotic process.
通过韧带切除使兔膝关节发生关节病，导致其不稳定。在患有关节病的膝关节滑液中发现了酸度和高碳酸血症，而氧分压正常。在关节病的软骨下骨中，骨内压和氧分压升高；骨内静脉造影显示静脉充血。组织学标本显示软骨下骨形成增加、软骨丢失和糖胺聚糖完全耗尽。滑膜增生，其下方组织出现纤维化。我们认为，尽管环境血流动力学和代谢变化本质上是继发性的，但可能在关节病过程中起重要作用。
