Kofoed H
Injury. 1986 Nov;17(6):391-4. doi: 10.1016/0020-1383(86)90078-1.
The purpose of the present study was to evaluate the environmental changes in synovial fluid and subchondral bone during synovitis in rabbits in which the knee joint on one side was subjected to a procedure causing instability; a traumatic synovitis rapidly developed. Three weeks following the procedure, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2) and hydrogen ion concentration (pH) were measured in vivo in the juxta-articular bone and in the synovial fluid of both the normal and the affected sides. Mass spectrometry was used for simultaneous registration of PO2 and PCO2, while a monocrystalline antimony pH electrode was used for simultaneous measurement of pH in vivo. Hypoxia, hypercapnia and relative acidity were found in synovial fluid and subchondral bone of knees with synovitis. The metabolic environment of synovial fluid and subchondral bone was considerably changed at the 3-week stage of experimental osteoarthritis and this was probably secondary to regional venous congestion.
本研究的目的是评估兔单侧膝关节因手术导致不稳定而发生滑膜炎期间，滑液和软骨下骨的环境变化；创伤性滑膜炎迅速发展。手术后三周，在正常侧和患侧的关节周围骨和滑液中，对体内的氧分压（PO2）、二氧化碳分压（PCO2）和氢离子浓度（pH）进行了测量。采用质谱法同时记录PO2和PCO2，而单晶锑pH电极用于体内pH的同步测量。在患有滑膜炎的膝关节的滑液和软骨下骨中发现了缺氧、高碳酸血症和相对酸性。在实验性骨关节炎的3周阶段，滑液和软骨下骨的代谢环境发生了显著变化，这可能继发于局部静脉充血。
