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尤卡坦植物群中的天然产物:结构多样性和生物活性。

Natural Products from the Yucatecan Flora: Structural Diversity and Biological Activity.

机构信息

Departamento de Recursos del Mar , Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional - Unidad Mérida , Mérida , México.

Laboratorio de Química Orgánica, Unidad de Biotecnología , Centro de Investigación Científica de Yucatán , Mérida , México.

出版信息

J Nat Prod. 2019 Mar 22;82(3):647-656. doi: 10.1021/acs.jnatprod.8b00959. Epub 2019 Mar 11.

DOI:10.1021/acs.jnatprod.8b00959
PMID:30855145
Abstract

The Yucatan Peninsula possesses a unique climate, geology, landscape, and biota that includes a distinct flora of over 2300 species; of these, close to 800 plants are used in what is known as Mayan traditional medicine, and about 170 are listed as native or endemic. Even though the flora of the Yucatan peninsula has been widely studied by naturalists and biologists, to date, phytochemical and pharmacological knowledge of most of the plants, including the medicinal plants, is limited. Presently, phytochemical studies carried out on plants from the Yucatecan flora have resulted in the identification of a wide variety of natural products that include flavonoids, terpenoids, polyketides, and phenolics with cytotoxic, antiprotozoal, antibacterial, anti-inflammatory, analgesic, antioxidant, and antifungal activities. This review describes the main findings in over 20 years (1992 to 2018) of exploring the natural product diversity of the Yucatecan flora.

摘要

尤卡坦半岛拥有独特的气候、地质、景观和生物群,其中包括超过 2300 种独特的植物;其中,近 800 种植物被用于被称为玛雅传统医学的用途,约 170 种被列为本地或特有种。尽管半岛的植物群已经被自然主义者和生物学家广泛研究,但迄今为止,大多数植物(包括药用植物)的植物化学和药理学知识仍然有限。目前,对来自尤卡坦植物群的植物进行的植物化学研究已经鉴定出了各种各样的天然产物,包括具有细胞毒性、抗原生动物、抗菌、抗炎、镇痛、抗氧化和抗真菌活性的黄酮类、萜类、多酮和酚类化合物。本文综述了 20 多年(1992 年至 2018 年)来探索尤卡坦植物群天然产物多样性的主要发现。

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