白藜芦醇在骨再生中的应用进展：口腔颌面外科学应用的进展和展望。
Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery.
机构信息
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123 Palermo, Italy.
Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy.
出版信息
Biomolecules. 2019 Mar 8;9(3):94. doi: 10.3390/biom9030094.
Abstract
The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts' proliferation and antagonist of osteoclasts' differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.
摘要
天然多酚白藜芦醇 (RSV) 具有许多对健康有益的作用，这是因为其生物学作用已被充分记录，表明其具有预防疾病的潜力，并可作为治疗多种慢性疾病的辅助药物。由于多项体外和体内研究都强调了 RSV 对骨骼的保护作用，既能促进成骨细胞的增殖，又能抑制破骨细胞的分化，因此 RSV 在牙科和颌面外科领域的应用具有很大的研究价值。本综述汇集了 RSV 用于骨组织再生的实验研究结果，包括其与支架和非输血血液成分联合应用的相关结果。
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