Argirion Ilona, Zarins Katie R, Defever Kali, Suwanrungruang Krittika, Chang Joanne T, Pongnikorn Donsuk, Chitapanarux Imjai, Sriplung Hutcha, Vatanasapt Patravoot, Rozek Laura S
University of Michigan School of Public Health, Ann Arbor, MI.
Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
J Glob Oncol. 2019 Mar;5:1-11. doi: 10.1200/JGO.18.00219.
Head and neck cancer is the sixth most common cancer in the world, and the largest burden occurs in developing countries. Although the primary risk factors have been well characterized, little is known about temporal trends in head and neck cancer across Thailand.
Head and neck squamous cell carcinoma (HNSCC) occurrences diagnosed between 1990 and 2014 were selected by International Classification of Diseases (10th revision; ICD10) code from the Songkhla, Lampang, Chiang Mai, and Khon Kaen cancer registries and the US SEER program for oral cavity (ICD10 codes 00, 03-06), tongue (ICD10 codes 01-02), pharynx (ICD10 codes 09-10, 12-14), and larynx (ICD10 code 32). The data were analyzed using R and Joinpoint regression software to determine age-standardized incidence rates and trends of annual percent change (APC). Incidence rates were standardized using the Segi (1960) population. Stratified linear regression models were conducted to assess temporal trends in early-onset HNSCC across 20-year age groups.
Although overall HNSCC rates are decreasing across all registries, subsite analyses demonstrate consistent decreases in both larynx and oral cavity cancers but suggest increases in tongue cancers among both sexes in the United States (APC, 2.36; APC, 0.77) and in pharyngeal cancer in Khon Kaen and US men (APC, 2.1 and 2.23, respectively). Age-stratified APC analyses to assess young-onset (< 60 years old) trends demonstrated increased incidence in tongue cancer in Thailand and the United States as well as in pharyngeal cancers in Khon Kaen men age 40 to 59 years and US men age 50 to 59 years.
Although overall trends in HNSCC are decreasing across both Thailand and the United States, there is reason to believe that the etiologic shift to oropharyngeal cancers in the United States may be occurring in Thailand.
头颈癌是全球第六大常见癌症，发展中国家负担最重。尽管主要危险因素已得到充分描述，但泰国头颈癌的时间趋势仍知之甚少。
从宋卡、南邦、清迈和孔敬癌症登记处以及美国监测、流行病学和最终结果（SEER）计划中，通过国际疾病分类（第10版；ICD10）代码选取1990年至2014年间诊断的头颈鳞状细胞癌（HNSCC）病例，涉及口腔（ICD10代码00、03 - 06）、舌（ICD10代码01 - 02）、咽（ICD10代码09 - 10、12 - 14）和喉（ICD10代码32）。使用R和Joinpoint回归软件分析数据，以确定年龄标准化发病率和年度百分比变化（APC）趋势。发病率采用世标（1960年）人口进行标准化。进行分层线性回归模型以评估20岁年龄组中早发性HNSCC的时间趋势。
尽管所有登记处的总体HNSCC发病率都在下降，但亚部位分析表明，喉癌和口腔癌发病率持续下降，但美国男女舌癌发病率上升（APC分别为2.36和0.77），孔敬和美国男性的咽癌发病率上升（APC分别为2.1和2.23）。评估年轻发病（<60岁）趋势的年龄分层APC分析表明，泰国和美国的舌癌发病率上升，孔敬40至59岁男性和美国50至59岁男性的咽癌发病率上升。
尽管泰国和美国的HNSCC总体趋势都在下降，但有理由相信美国口咽癌的病因转变可能正在泰国发生。
