Swire F M, Marsden C A, Barber C, Birmingham A T
Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, UK.
Psychopharmacology (Berl). 1989;98(3):425-9. doi: 10.1007/BF00451699.
Measurements of the amplitude and latency of the P3b component of the event-related potential (ERP), simple reaction time (SRT) and four psychomotor tests (VAS, DSST, DSp and CFF) were made on 12 male subjects (aged 19-24 years) 1.0-1.5 and 4.0-4.5 h after single oral doses of triprolidine (7.5 mg), terfenadine (60 mg) and placebo. Neither triprolidine nor terfenadine changed P3b amplitude or latency although VAS, CFF and DSST scores were significantly altered by triprolidine at 1.0-1.5 h after dosage. These results suggest that the P3b is too robust to reflect the mild sedative properties of an H1-receptor antihistamine, or that H1-receptors are not involved in P3b generation.
对12名年龄在19至24岁之间的男性受试者在单次口服7.5毫克曲普利啶、60毫克特非那定和安慰剂后1.0至1.5小时以及4.0至4.5小时，进行了事件相关电位（ERP）的P3b成分的振幅和潜伏期、简单反应时间（SRT）以及四项心理运动测试（视觉模拟评分法、数字符号替换测验、数字划消测验和临界闪光融合频率）的测量。尽管在给药后1.0至1.5小时曲普利啶使视觉模拟评分法、临界闪光融合频率和数字符号替换测验得分发生显著改变，但曲普利啶和特非那定均未改变P3b的振幅或潜伏期。这些结果表明，P3b过于稳定，无法反映H1受体抗组胺药的轻度镇静特性，或者H1受体不参与P3b的产生。
