Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
Chemistry. 2013 Feb 4;19(6):1858-71. doi: 10.1002/chem.201202798. Epub 2013 Jan 16.
Transition-metal-catalyzed alkenylation of enolates provides a direct method to synthesize broadly useful β,γ-unsaturated carbonyl compounds from the corresponding carbonyl compound and alkenyl halides. Despite being reported in the early seventies, this reaction class saw little development for many years. In the past decade, however, efforts to develop this reaction further have increased considerably, and many research groups have reported efficient coupling protocols, including enantioselective versions. These reactions most commonly employ palladium catalysts, but there are also some important reports using nickel. There are many examples of this powerful transformation being used in the synthesis of complex natural products.
过渡金属催化烯醇盐的烯基化反应为从相应的羰基化合物和烯基卤化物合成广泛有用的β,γ-不饱和羰基化合物提供了一种直接的方法。尽管该反应类型早在 70 年代就有报道，但多年来发展甚微。然而，在过去的十年中，进一步开发该反应的努力大大增加，许多研究小组已经报道了有效的偶联方案，包括对映选择性版本。这些反应最常用钯催化剂，但也有一些使用镍的重要报道。在复杂天然产物的合成中，有许多这种强大转化的例子。
