201 Women's Building, Department of Exercise Science, Syracuse University, Syracuse, NY 13244, USA.
107 College Place, Department of Biology, Syracuse University, Syracuse, NY 13244, USA.
Int J Mol Sci. 2019 Mar 7;20(5):1178. doi: 10.3390/ijms20051178.
Oxidative stress resulting from decreased antioxidant protection and increased reactive oxygen and nitrogen species (RONS) production may contribute to muscle mass loss and dysfunction during aging. Curcumin is a phenolic compound shown to upregulate antioxidant defenses and directly quench RONS in vivo. This study determined the impact of prolonged dietary curcumin exposure on muscle mass and function of aged rats. Thirty-two-month-old male F344xBN rats were provided a diet with or without 0.2% curcumin for 4 months. The groups included: control (CON; = 18); 0.2% curcumin (CUR; = 18); and pair-fed (PAIR; = 18) rats. CUR rats showed lower food intake compared to CON, making PAIR a suitable comparison group. CUR rats displayed larger plantaris mass and force production (vs. PAIR). Nuclear fraction levels of nuclear factor erythroid-2 related-factor-2 were greater, and oxidative macromolecule damage was lower in CUR (vs. PAIR). There were no significant differences in measures of antioxidant status between any of the groups. No difference in any measure was observed between CUR and CON rats. Thus, consumption of curcumin coupled with reduced food intake imparted beneficial effects on aged skeletal muscle. The benefit of curcumin on aging skeletal muscle should be explored further.
氧化应激是由于抗氧化保护减少和活性氧和氮物种 (RONS) 产生增加而导致的，可能导致衰老过程中肌肉质量和功能下降。姜黄素是一种酚类化合物，已被证明可上调抗氧化防御系统，并直接在体内淬灭 RONS。本研究旨在确定长期饮食姜黄素暴露对老年大鼠肌肉质量和功能的影响。将 32 月龄的雄性 F344xBN 大鼠分为对照组（CON；n = 18）、0.2%姜黄素组（CUR；n = 18）和等热量喂养组（PAIR；n = 18），并分别给予含有或不含有 0.2%姜黄素的饮食 4 个月。与 CON 组相比，CUR 组大鼠的食物摄入量较低，因此 PAIR 组是合适的对照组。CUR 组大鼠的比目鱼肌质量和收缩力更大（与 PAIR 组相比）。CUR 组的核因子红细胞 2 相关因子 2 的核蛋白水平更高，氧化大分子损伤水平更低（与 PAIR 组相比）。各组的抗氧化状态测量值均无显著差异。CUR 组和 CON 组之间的任何测量值均无差异。因此，姜黄素的摄入与食物摄入量的减少共同对衰老的骨骼肌产生了有益的影响。应该进一步探索姜黄素对衰老骨骼肌的益处。
