Stegink L D, Zike W L, Andersen D W, Warwick T R
Metabolism. 1986 Jun;35(6):519-23. doi: 10.1016/0026-0495(86)90008-9.
Utilization of intravenously administered oligosaccharides was tested in postsurgical patients by infusing them simultaneously with glucose and amino acids. Thirty two patients were infused with one of two parenteral regimens for four-day periods. Twenty-two patients received a nutritional regimen providing 46 g glucose, 32.5 g amino acids, and 45 g oligosaccharides per liter, while the remaining ten patients received the same solution without oligosaccharides. Patients infused with the test solution received an overall four-day mean +/- SD of 106 +/- 24.2 g oligosaccharide per day. The mean overall four-day excretion of total glucose (free plus oligosaccharide bound) was significantly higher (P less than 0.001) in patients infused with oligosaccharides (46.1 +/- 29.0 g/d) than in reference patients (1.19 +/- 1.20 g/d). Of the total carbohydrate excreted in patients receiving oligosaccharides, 11.3 +/- 13.1 g/d were glucose, 14.8 +/- 13.1 g/d were maltose plus maltotriose, and 20.8 +/- 19.3 g/d were oligosaccharides of maltotetraose size or larger. Although overall utilization of infused oligosaccharide for all patients was only 58.5% +/- 23.1%, three of the patients showed unexpectedly good utilization (94.6% +/- 1.24%).
通过将静脉注射的低聚糖与葡萄糖和氨基酸同时输注，对术后患者使用低聚糖的情况进行了测试。32名患者接受了两种肠外方案中的一种，为期四天。22名患者接受的营养方案为每升提供46克葡萄糖、32.5克氨基酸和45克低聚糖，而其余10名患者接受不含低聚糖的相同溶液。输注测试溶液的患者每天接受的低聚糖总量的四天平均值±标准差为106±24.2克。输注低聚糖的患者（46.1±29.0克/天）中总葡萄糖（游离加结合的低聚糖）的四天平均排泄量显著高于参考患者（1.19±1.20克/天）（P<0.001）。在接受低聚糖的患者中排泄的总碳水化合物中，葡萄糖为11.3±13.1克/天，麦芽糖加麦芽三糖为14.8±13.1克/天，麦芽四糖大小或更大的低聚糖为20.8±19.3克/天。尽管所有患者对输注低聚糖的总体利用率仅为58.5%±23.1%，但有三名患者显示出出乎意料的良好利用率（94.6%±1.24%）。
