Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, MX.
Centro de Investigación Aplicada en Ambiente y Salud, CIACYT, Facultad de Medicina, Universidad Autónoma de San Luis Potosí. Av. Venustiano Carranza 2405, CP 78210, San Luis Potosí, SLP, MX.
Ann Glob Health. 2018 Jul 27;84(2):250-256. doi: 10.29024/aogh.912.
Exposure to contaminant mixtures in developing countries is an important public health issue. Children are identified as the most susceptible group to adverse health effects due to the exposure.
The aim of this study was to conduct a screening for mixture pollutants in Mexican children in urban marginalized communities.
We analyzed children (aged 6-12 years old) who resided in four urban marginalized communities in San Luis Potosi, Mexico: i) Bellas Lomas (BEL), a site with vehicular traffic; ii) Tercera Chica (TC), a site with brick kilns; Iii) Rincon de San Jose (SJR), a site with a hazardous waste landfill; and (iv) Morales (MOR) a metallurgical zone with copper-arsenic and electrolytic zinc smelters. Polycyclic Aromatic Hydrocarbons (1-hydroxypyrene (1-OHP)), benzene (trans, trans-muconic acid (t,t-MA), manganese, arsenic and fluoride were quantified in urine and lead in blood samples.
Our results indicate that median exposures to manganese were 4.4, 5.2, 5.8 and 6.3 μg/L for BEL, TC, SJR and MOR, respectively. For BEL, fluoride was present at a higher concentration with 2.3 mg/L followed by MOR, TC and SJR with 1.7, 1.5 and 1.2 mg/L respectively. The highest concentrations of arsenic that were found were 11 μg/L in MOR and lead concentration was reported between 4.2 and 6.8 μg/dL, in BEL, TC and MOR. 1-OHP and t,t-MA were higher in TC (0.23 μmol/mol creatinine (cr), 429.7 μg/g cr, respectively) followed by SJR (0.09 μmol/mol cr, 427.4 μg/g cr), MOR (0.03 μmol/mol cr, 258.6 μg/g cr) and BEL (0.06 μmol/mol cr, 220.6 μg/g cr).
Considering the large number of people, especially children, exposed to multiple pollutants, it is important to design effective intervention programs that reduce exposure and the resultant risk in the numerous urban marginalized communities in Mexico.
发展中国家接触污染物混合物是一个重要的公共卫生问题。由于接触，儿童被确定为易受不良健康影响的最脆弱群体。
本研究旨在对墨西哥城市边缘社区的儿童进行混合物污染物筛查。
我们分析了居住在墨西哥圣路易斯波托西的四个城市边缘社区的儿童（6-12 岁）：i）Bellas Lomas（BEL），一个有车辆交通的地点；ii）Tercera Chica（TC），一个有砖窑的地点；iii）Rincon de San Jose（SJR），一个有危险废物垃圾填埋场的地点；和 iv）Morales（MOR），一个有铜砷和电解锌冶炼厂的冶金区。尿液中定量了多环芳烃（1-羟基芘（1-OHP））、苯（反式，顺式-粘康酸（t，t-MA））、锰、砷和氟化物，血液样本中定量了铅。
我们的结果表明，BEL、TC、SJR 和 MOR 的儿童中位数锰暴露分别为 4.4、5.2、5.8 和 6.3μg/L。对于 BEL，氟化物的浓度更高，为 2.3mg/L，其次是 MOR、TC 和 SJR，分别为 1.7、1.5 和 1.2mg/L。发现的最高砷浓度为 11μg/L，在 MOR，铅浓度报告为 4.2 至 6.8μg/dL，在 BEL、TC 和 MOR。TC（0.23μmol/mol 肌酐（cr），429.7μg/g cr）中 1-OHP 和 t，t-MA 浓度较高，其次是 SJR（0.09μmol/mol cr，427.4μg/g cr）、MOR（0.03μmol/mol cr，258.6μg/g cr）和 BEL（0.06μmol/mol cr，220.6μg/g cr）。
考虑到大量的人，特别是儿童，接触多种污染物，有必要设计有效的干预计划，以减少墨西哥众多城市边缘社区的暴露和由此产生的风险。
