Biology Program, New York University Abu Dhabi, PO Box 129188, Saadiyat Island Campus, Abu Dhabi, United Arab Emirates.
Cell Mol Life Sci. 2019 Jun;76(11):2171-2183. doi: 10.1007/s00018-019-03061-0. Epub 2019 Mar 15.
Despite continuing advances in the development of biomacromolecules for therapeutic purposes, successful application of these often large and hydrophilic molecules has been hindered by their inability to efficiently traverse the cellular plasma membrane. In recent years, cell-penetrating peptides (CPPs) have received considerable attention as a promising class of delivery vectors due to their ability to mediate the efficient import of a large number of cargoes in vitro and in vivo. However, the lack of target specificity of CPPs remains a major obstacle to their clinical development. To address this issue, researchers have developed strategies in which chemotherapeutic drugs are conjugated to cancer targeting peptides (CTPs) that exploit the unique characteristics of the tumor microenvironment or cancer cells, thereby improving cancer cell specificity. This review highlights several of these strategies that are currently in use, and discusses how multi-component nanoparticles conjugated to CTPs can be designed to provide a more efficient cancer therapeutic delivery strategy.
尽管在生物大分子治疗应用方面不断取得进展，但由于这些通常较大和亲水的分子无法有效地穿透细胞浆膜，其成功应用受到了阻碍。近年来，由于细胞穿透肽（CPPs）能够介导大量货物在体外和体内的有效导入，因此作为一类有前途的递药载体受到了相当多的关注。然而，CPPs 的缺乏靶向特异性仍然是其临床开发的主要障碍。为了解决这个问题，研究人员开发了一些策略，将化疗药物与利用肿瘤微环境或癌细胞独特特征的癌症靶向肽（CTP）偶联，从而提高癌细胞的特异性。本综述强调了目前正在使用的几种策略，并讨论了如何设计与 CTP 偶联的多组分纳米粒子以提供更有效的癌症治疗递药策略。
