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Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating.癌细胞的代谢清除：当形势艰难时，强者继续进食。
Br J Cancer. 2016 Sep 6;115(6):635-40. doi: 10.1038/bjc.2016.256. Epub 2016 Aug 18.
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Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.糖酵解代谢相关蛋白表达在结直肠癌、淋巴结及肝转移中的意义
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Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.缺氧介导的MCT1表达上调支持胶质母细胞瘤的糖酵解表型。
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Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment.酸分泌离子转运体在三维微环境中对乳腺癌细胞生长调控中的作用
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Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis.肿瘤微环境中促淋巴管生成串扰对淋巴癌转移的影响。
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Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells.肿瘤微环境中的外泌体：正常细胞与癌细胞之间相互作用的概述
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Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.肿瘤微环境中pH值失调阻碍癌症治疗。
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Posttranscriptional control of T cell effector function by aerobic glycolysis.有氧糖酵解对 T 细胞效应功能的转录后控制。
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Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.单羧酸转运蛋白（MCTs）在脑胶质瘤中的表达及其作为治疗靶点的应用。
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有氧糖酵解与癌症代谢及微环境中的高乳酸水平

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment.

作者信息

Jiang Bo

机构信息

Department of Oncology, Avis General Hospital, Beijing, China.

出版信息

Genes Dis. 2017 Feb 14;4(1):25-27. doi: 10.1016/j.gendis.2017.02.003. eCollection 2017 Mar.

DOI:10.1016/j.gendis.2017.02.003
PMID:30258905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6136593/
Abstract

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments.

摘要

代谢异常是癌症的一个标志。大约100年前，诺贝尔奖获得者奥托·海因里希·瓦尔堡首次描述了癌细胞中糖酵解速率很高的现象。最近，关于癌症代谢的越来越多新观点补充了这一假说，包括葡萄糖摄取、乳酸生成与分泌、微环境酸化以及癌症免疫逃逸。在此，我们简要回顾产生乳酸的代谢途径，并讨论较高水平的乳酸在癌症微环境中的作用。