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大鼠免疫球蛋白重链基因座定位于6号染色体。

Localization of the rat immunoglobulin heavy chain locus to chromosome 6.

作者信息

Pear W S, Wahlström G, Szpirer J, Levan G, Klein G, Sümegi J

出版信息

Immunogenetics. 1986;23(6):393-5. doi: 10.1007/BF00372672.

DOI:10.1007/BF00372672
PMID:3087869
Abstract

We have previously used rat/mouse somatic cell hybrids to localize the rat c-myc gene to chromosome 7 (Sümegi et al. 1983) and the rat immunoglobulin kappa locus to chromosome 4 (Perlmann et al. 1985). We now report that by utilizing rat/mouse somatic cell hybrids, we have localized the rat immunoglobulin heavy chain locus to chromosome 6.

摘要

我们之前利用大鼠/小鼠体细胞杂种将大鼠c-myc基因定位到了7号染色体(Sümegi等人,1983年),并将大鼠免疫球蛋白κ基因座定位到了4号染色体(Perlmann等人,1985年)。我们现在报告,通过利用大鼠/小鼠体细胞杂种,我们已将大鼠免疫球蛋白重链基因座定位到了6号染色体。

相似文献

1
Localization of the rat immunoglobulin heavy chain locus to chromosome 6.大鼠免疫球蛋白重链基因座定位于6号染色体。
Immunogenetics. 1986;23(6):393-5. doi: 10.1007/BF00372672.
2
Localization of the rat immunoglobulin lambda light chain locus to chromosome 11.大鼠免疫球蛋白λ轻链基因座定位于11号染色体。
Immunogenetics. 1988;28(3):182-3. doi: 10.1007/BF00375857.
3
Immunoglobulin production by human-mouse somatic cell hybrids.人-小鼠体细胞杂种的免疫球蛋白产生
Trans Assoc Am Physicians. 1977;90:281-5.
4
Chromosomal location of the genes for human immunoglobulin heavy chains.
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3416-9. doi: 10.1073/pnas.76.7.3416.
5
The c-myc oncogene is translocated to the involved chromosome 12 in mouse plasmacytoma.在小鼠浆细胞瘤中,c-myc癌基因易位至受累的12号染色体。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4212-6. doi: 10.1073/pnas.82.12.4212.
6
Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.编码小鼠免疫球蛋白重链的结构基因簇的染色体定位。
J Exp Med. 1980 Jun 1;151(6):1545-50. doi: 10.1084/jem.151.6.1545.
7
Immunoglobulin heavy chain genes in humans are located on chromosome.人类免疫球蛋白重链基因位于染色体上。
Ann Hum Genet. 1981 Oct;45(4):331-5. doi: 10.1111/j.1469-1809.1981.tb00346.x.
8
Regional location of T cell receptor gene Ti alpha on human chromosome 14.人类14号染色体上T细胞受体基因Tiα的区域定位。
J Exp Med. 1985 Jul 1;162(1):387-92. doi: 10.1084/jem.162.1.387.
9
Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas.大鼠/小鼠杂交骨髓瘤中大鼠免疫球蛋白的染色体分离与表达
Immunogenetics. 1980;10(2):125-31. doi: 10.1007/BF01561561.
10
Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.人类T细胞受体α链基因:位于14号染色体上与T细胞肿瘤相关的区域。
Science. 1985 Mar 1;227(4690):1044-7. doi: 10.1126/science.3919442.

引用本文的文献

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A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.一张大鼠遗传连锁图谱以及小鼠或人类同源大鼠基因的比较图谱。
Mamm Genome. 1994 Feb;5(2):63-83. doi: 10.1007/BF00292332.
2
Localization of the IGHG, PRKACB, and TNP2 genes in pigs by in situ hybridization.
Mamm Genome. 1994 Apr;5(4):195-8. doi: 10.1007/BF00360544.
3
Localization of the rat immunoglobulin lambda light chain locus to chromosome 11.大鼠免疫球蛋白λ轻链基因座定位于11号染色体。
Immunogenetics. 1988;28(3):182-3. doi: 10.1007/BF00375857.

本文引用的文献

1
Myc/Ig juxtaposition by chromosomal translocations: some new insights, puzzles and paradoxes.染色体易位导致的Myc/Ig并置:一些新见解、谜题与悖论
Immunol Today. 1985 Jul;6(7):208-15. doi: 10.1016/0167-5699(85)90036-2.
2
Non-random chromosomal changes involving chromosomes 6 and 7 in spontaneous rat immunocytomas.自发大鼠免疫细胞瘤中涉及6号和7号染色体的非随机染色体变化。
Int J Cancer. 1982 Apr 15;29(4):431-7. doi: 10.1002/ijc.2910290412.
3
Characterization and molecular cloning of the mRNA for the heavy (epsilon) chain of rat immunoglobulin E.
4
6;7 chromosomal translocation in spontaneously arising rat immunocytomas: evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target.自发产生的大鼠免疫细胞瘤中的6;7染色体易位:c-myc断点聚类以及同型表达与c-myc靶点之间相关性的证据
Mol Cell Biol. 1988 Jan;8(1):441-51. doi: 10.1128/mcb.8.1.441-451.1988.
5
Chromosome assignments of the genes for glucocorticoid receptor, myelin basic protein, leukocyte common antigen, and TRPM2 in the rat.大鼠中糖皮质激素受体、髓鞘碱性蛋白、白细胞共同抗原和TRPM2基因的染色体定位。
Biochem Genet. 1991 Jun;29(5-6):275-86. doi: 10.1007/BF00590108.
6
Comparative mapping of IGHG1, IGHM, FES, and FOS in domestic cattle.家牛中IGHG1、IGHM、FES和FOS的比较图谱分析
Immunogenetics. 1992;36(3):157-65. doi: 10.1007/BF00661092.
大鼠免疫球蛋白E重链(ε链)mRNA的特性鉴定与分子克隆
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1264-8. doi: 10.1073/pnas.79.4.1264.
4
5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains.免疫球蛋白重链恒定区基因的5'侧翼区域在近交系小鼠品系的种系中表现出长度多态性。
Cell. 1980 Nov;22(1 Pt 1):187-96. doi: 10.1016/0092-8674(80)90167-1.
5
Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas.大鼠/小鼠杂交骨髓瘤中大鼠免疫球蛋白的染色体分离与表达
Immunogenetics. 1980;10(2):125-31. doi: 10.1007/BF01561561.
6
Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation.大鼠c-myc癌基因位于7号染色体上,并在伴有t(6;7)染色体易位的免疫细胞瘤中发生重排。
Nature. 1983;306(5942):497-8. doi: 10.1038/306497a0.
7
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.一种将DNA限制性内切酶片段放射性标记至高比活度的技术。附录
Anal Biochem. 1984 Feb;137(1):266-7. doi: 10.1016/0003-2697(84)90381-6.
8
Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and alpha-fetoprotein genes and assignment to chromosome 14.通过小鼠-大鼠体细胞杂交进行大鼠基因定位:白蛋白和甲胎蛋白基因的同线性及定位于第14号染色体
Cytogenet Cell Genet. 1984;38(2):142-9. doi: 10.1159/000132047.
9
Control of serum protein production in hepatocyte hybridomas: immortalization and expression of normal hepatocyte genes.肝细胞杂交瘤中血清蛋白产生的调控:正常肝细胞基因的永生化与表达
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6616-20. doi: 10.1073/pnas.77.11.6616.
10
The rat immunoglobulin kappa light chain locus is on chromosome 4.大鼠免疫球蛋白κ轻链基因座位于4号染色体上。
Immunogenetics. 1985;22(1):97-100. doi: 10.1007/BF00430599.