给大鼠注射A组链球菌细胞壁会导致白细胞介素2缺乏。
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.
作者信息
Ridge S C, Zabriskie J B, Osawa H, Diamantstein T, Oronsky A L, Kerwar S S
出版信息
J Exp Med. 1986 Jul 1;164(1):327-32. doi: 10.1084/jem.164.1.327.
Abstract
Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall-treated rats (Lewis and Fischer) are deficient in the synthesis of IL-2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
摘要
给Lewis大鼠腹腔注射A组链球菌细胞壁可诱发慢性关节炎，而Fischer品系大鼠对该病变的发展具有抗性。用细胞壁处理过的大鼠（Lewis和Fischer）的脾细胞合成白细胞介素-2（IL-2）的能力不足。利用一种针对大鼠IL-2受体的单克隆抗体，目前的研究表明，用细胞壁处理过的大鼠脾脏上IL-2受体的表达是正常的。然而，向用刀豆蛋白A培养的脾细胞中添加外源性IL-2并不能刺激有丝分裂反应。
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