给大鼠注射A组链球菌细胞壁会导致白细胞介素2缺乏。
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.
作者信息
Ridge S C, Zabriskie J B, Osawa H, Diamantstein T, Oronsky A L, Kerwar S S
出版信息
J Exp Med. 1986 Jul 1;164(1):327-32. doi: 10.1084/jem.164.1.327.
Abstract
Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall-treated rats (Lewis and Fischer) are deficient in the synthesis of IL-2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
摘要
给Lewis大鼠腹腔注射A组链球菌细胞壁可诱发慢性关节炎，而Fischer品系大鼠对该病变的发展具有抗性。用细胞壁处理过的大鼠（Lewis和Fischer）的脾细胞合成白细胞介素-2（IL-2）的能力不足。利用一种针对大鼠IL-2受体的单克隆抗体，目前的研究表明，用细胞壁处理过的大鼠脾脏上IL-2受体的表达是正常的。然而，向用刀豆蛋白A培养的脾细胞中添加外源性IL-2并不能刺激有丝分裂反应。
相似文献
1
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.给大鼠注射A组链球菌细胞壁会导致白细胞介素2缺乏。
J Exp Med. 1986 Jul 1;164(1):327-32. doi: 10.1084/jem.164.1.327.
2
The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains.大鼠A组链球菌细胞壁诱导的多关节炎的发病机制。对关节炎抗性和易感性近交系大鼠品系的比较研究。
Arthritis Rheum. 1983 Dec;26(12):1442-51. doi: 10.1002/art.1780261205.
3
Streptococcal cell wall arthritis: studies with nude (athymic) inbred Lewis rats.
Cell Immunol. 1985 Nov;96(1):231-4. doi: 10.1016/0008-8749(85)90354-5.
4
5C6-F4, a novel 100,000-dalton rat lymphocyte activation antigen defined by monoclonal antibody.5C6-F4，一种由单克隆抗体定义的新型100,000道尔顿大鼠淋巴细胞激活抗原。
J Immunol. 1986 Jun 1;136(11):3968-76.
5
Studies on the effect of D-penicillamine, gold thioglucose and methotrexate on streptococcal cell wall arthritis.
J Rheumatol. 1986 Oct;13(5):895-8.
6
Inhibitors of reactive oxygen intermediates suppress bacterial cell wall-induced arthritis.活性氧中间体抑制剂可抑制细菌细胞壁诱导的关节炎。
J Immunol. 1991 Oct 15;147(8):2559-64.
7
T cell responses to streptococcal antigens in rats: relation to susceptibility to streptococcal cell wall-induced arthritis.大鼠对链球菌抗原的T细胞反应：与对链球菌细胞壁诱导性关节炎易感性的关系。
Cell Immunol. 1988 Oct 1;116(1):216-29. doi: 10.1016/0008-8749(88)90222-5.
8
Gut flora induces and maintains resistance against streptococcal cell wall-induced arthritis in F344 rats.肠道菌群可诱导并维持F344大鼠对链球菌细胞壁诱导性关节炎的抵抗力。
Clin Exp Immunol. 1992 May;88(2):313-7. doi: 10.1111/j.1365-2249.1992.tb03079.x.
9
10
Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.在对链球菌细胞壁关节炎易感的刘易斯大鼠中，炎症介质诱导的下丘脑-垂体-肾上腺轴激活存在缺陷。
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2374-8. doi: 10.1073/pnas.86.7.2374.
引用本文的文献
1
Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy.用于开发新型抗关节炎分子的啮齿动物临床前模型：比较生物学及评估疗效的首选方法
J Biomed Biotechnol. 2011;2011:569068. doi: 10.1155/2011/569068. Epub 2010 Dec 28.
2
Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis?经细菌致敏的小鼠T细胞对软骨成分的反应：关节炎发病机制的线索？
Clin Exp Immunol. 1988 Apr;72(1):9-14.
3
Immunosuppressive macrophages induced by arthropathic peptidoglycan-polysaccharide polymers from bacterial cell walls.由细菌细胞壁中的关节病肽聚糖 - 多糖聚合物诱导产生的免疫抑制性巨噬细胞。
Clin Exp Immunol. 1988 Dec;74(3):365-70.
4
Bacterial cell wall-induced immunosuppression. Role of transforming growth factor beta.细菌细胞壁诱导的免疫抑制。转化生长因子β的作用。
J Exp Med. 1988 Oct 1;168(4):1403-17. doi: 10.1084/jem.168.4.1403.
5
A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.促肾上腺皮质激素释放激素生物合成中的中枢神经系统缺陷与Lewis大鼠对链球菌细胞壁诱导性关节炎的易感性相关。
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4771-5. doi: 10.1073/pnas.86.12.4771.
6
Streptococcal cell wall arthritis. Passive transfer of disease with a T cell line and crossreactivity of streptococcal cell wall antigens with Mycobacterium tuberculosis.链球菌细胞壁关节炎。疾病通过T细胞系的被动转移以及链球菌细胞壁抗原与结核分枝杆菌的交叉反应性。
J Exp Med. 1989 Aug 1;170(2):369-82. doi: 10.1084/jem.170.2.369.
7
Experimental animal models resembling rheumatoid arthritis.类似于类风湿性关节炎的实验动物模型。
Clin Rheumatol. 1992 Mar;11(1):41-7. doi: 10.1007/BF02207082.
本文引用的文献
1
Cell-mediated immune response during experimental arthritis induced in rats with streptococcal cell walls.用链球菌细胞壁诱导大鼠实验性关节炎期间的细胞介导免疫反应。
Clin Exp Immunol. 1980 Dec;42(3):441-9.
2
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.系统性红斑狼疮患者培养淋巴细胞白细胞介素 -2 的产生及反应降低。
J Clin Invest. 1982 Jun;69(6):1388-92. doi: 10.1172/jci110579.
3
Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus.类风湿关节炎和系统性红斑狼疮中的白细胞介素2缺乏症。
Clin Immunol Immunopathol. 1984 Apr;31(1):109-17. doi: 10.1016/0090-1229(84)90195-8.
4
5
The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains.大鼠A组链球菌细胞壁诱导的多关节炎的发病机制。对关节炎抗性和易感性近交系大鼠品系的比较研究。
Arthritis Rheum. 1983 Dec;26(12):1442-51. doi: 10.1002/art.1780261205.
6
Murine models of systemic lupus erythematosus.系统性红斑狼疮的小鼠模型。
Adv Immunol. 1985;37:269-390. doi: 10.1016/s0065-2776(08)60342-9.
7
Arthritis in rats after systemic injection of streptococcal cells or cell walls.全身注射链球菌细胞或细胞壁后大鼠的关节炎
J Exp Med. 1977 Dec 1;146(6):1585-602. doi: 10.1084/jem.146.6.1585.
8
T cell growth factor: parameters of production and a quantitative microassay for activity.T细胞生长因子：产生参数及活性的定量微量测定法。
J Immunol. 1978 Jun;120(6):2027-32.
Zotero 插件