Miyasaka N, Nakamura T, Russell I J, Talal N
Clin Immunol Immunopathol. 1984 Apr;31(1):109-17. doi: 10.1016/0090-1229(84)90195-8.
The ability of peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjogren's syndrome (SS) to produce interleukin 2 (IL-2) and respond to it in-vitro was examined. Phytohemagglutinin-stimulated lymphocytes from over half of the SLE patients exhibited a decreased ability to produce IL-2 while their concanavalin A-generated blast cells responded normally to exogenous IL-2. Lymphocytes from RA patients not only produced less IL-2 than normals (P less than 0.001), but also responded poorly to exogenous IL-2 (P = 0.011). These abnormalities did not correlate with the patient's age, sex, duration of disease, or disease activity. Production of and response to IL-2 was widely varied among patients with SS and not different from controls. The decreased response of RA lymphocytes to IL-2 may result from a smaller number of cell surface IL-2 receptors since IL-2 adsorption to RA cells was lower than to either SLE or normal cells. These data suggest that IL-2-related abnormalities may play a role in the disordered immunoregulation characteristic of RA and perhaps of SLE.
对系统性红斑狼疮（SLE）、类风湿性关节炎（RA）和干燥综合征（SS）患者外周血淋巴细胞产生白细胞介素2（IL-2）及在体外对其作出反应的能力进行了检测。超过半数SLE患者经植物血凝素刺激的淋巴细胞产生IL-2的能力下降，而其经刀豆蛋白A诱导产生的母细胞对外源性IL-2反应正常。RA患者的淋巴细胞不仅产生的IL-2比正常人少（P<0.001），而且对外源性IL-2反应也较差（P = 0.011）。这些异常情况与患者的年龄、性别、病程或疾病活动度均无关联。SS患者中IL-2的产生及反应差异很大，与对照组无差异。RA淋巴细胞对IL-2反应降低可能是由于细胞表面IL-2受体数量较少，因为IL-2与RA细胞的结合低于与SLE细胞或正常细胞的结合。这些数据表明，与IL-2相关的异常可能在RA以及或许在SLE的免疫调节紊乱中起作用。
