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临床复杂分离株的种属分布与大环内酯类药物敏感性研究

Species Distribution and Macrolide Susceptibility of Complex Clinical Isolates.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

出版信息

Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.02331-18. Print 2019 Jun.

DOI:10.1128/AAC.02331-18
PMID:30885902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6535553/
Abstract

The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were , followed by , , , and Most , , and isolates were inducibly resistant to clarithromycin, whereas two-thirds of the isolates were clarithromycin susceptible. Clarithromycin-resistant isolates exhibited common mutations of (39), potentially involved in clarithromycin resistance.

摘要

对于 复杂(MFC)中的物种分布和可诱导大环内酯类耐药性的了解有限。在 90 株主要来自呼吸道的 MFC 临床分离株中, 位居首位,其次是 、 、 和 。大多数 、 和 分离株对克拉霉素具有诱导耐药性,而三分之二的 分离株对克拉霉素敏感。克拉霉素耐药的 分离株表现出常见的(39)突变,这些突变可能与克拉霉素耐药性有关。

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