Askari Mitra, Yazdani Reza
Quintessence Int. 2019;50(4):320-329. doi: 10.3290/j.qi.a42096.
Dentin hypersensitivity (DH) is a common problem with multifactorial etiology. It is characterized by a short, sharp pain due to exposed dentin usually at the cervical margin. This randomized clinical trial aimed to evaluate the efficacy of two desensitizing agents for reduction of dentin hypersensitivity (DH) following periodontal surgeries.
This study evaluated 96 patients who had one or two teeth with DH (120 teeth). The teeth were randomly allocated into four groups for treatment with 10% ethanolic extract of propolis (group 1), 30% ethanolic extract of propolis (group 2), Single Bond Universal dentin bonding agent (group 3), and distilled water as placebo (group 4). The degree of DH was determined according to the patients' response to tactile and air blast stimuli using a visual analog scale (VAS). The level of pain was also recorded before treatment and at 1, 7, 14, 21, 60 and 90 days after the treatment.
All interventions (groups 1 to 3) were significantly effective in decreasing DH, and 10% and 30% ethanolic extracts of propolis were equally effective. The dentin bonding agent was completely effective at all time points. All three interventions (groups 1 to 3) effectively decreased DH at 60 and 90 days.
This clinical trial showed all interventions were more effective than the placebo in decreasing DH. The tested propolis extracts were equally effective irrespective of their concentration. Application of Single Bond Universal had a fast relieving effect on DH. Propolis extracts and dentin bonding agent were equally effective in relieving DH in the long term.
DH following periodontal surgery causes patient discomfort and hinders everyday activities. Propolis is a natural desensitizing agent with antimicrobial and anti-inflammatory properties, healing effects, and cariostatic activity. It also stimulates reparative dentin formation. Flavonoids and cinnamic acid derivatives are the main biologically active components in the composition of propolis. According to the results of this study, application of propolis is recommended for patients with mild or moderate pain. Dentin bonding agent could be a better choice when immediate effect is needed.
牙本质过敏症（DH）是一种病因多因素的常见问题。其特征是由于通常在颈部边缘暴露的牙本质引起的短暂、尖锐疼痛。这项随机临床试验旨在评估两种脱敏剂在牙周手术后降低牙本质过敏症（DH）的疗效。
本研究评估了96例有一颗或两颗牙齿患有DH的患者（共120颗牙齿）。这些牙齿被随机分为四组，分别用10%蜂胶乙醇提取物（第1组）、30%蜂胶乙醇提取物（第2组）、单键通用牙本质粘结剂（第3组）和蒸馏水作为安慰剂（第4组）进行治疗。根据患者对触觉和空气喷射刺激的反应，使用视觉模拟量表（VAS）确定DH的程度。在治疗前以及治疗后1、7、14、21、60和90天记录疼痛水平。
所有干预措施（第1至3组）在降低DH方面均具有显著效果，10%和30%的蜂胶乙醇提取物效果相同。牙本质粘结剂在所有时间点均完全有效。所有三种干预措施（第1至3组）在60天和90天时均有效降低了DH。
这项临床试验表明，所有干预措施在降低DH方面均比安慰剂更有效。所测试的蜂胶提取物无论浓度如何，效果相同。应用单键通用粘结剂对DH有快速缓解作用。蜂胶提取物和牙本质粘结剂在长期缓解DH方面效果相同。
牙周手术后的DH会导致患者不适并妨碍日常活动。蜂胶是一种具有抗菌、抗炎特性、愈合作用和抑龋活性的天然脱敏剂。它还能刺激修复性牙本质的形成。黄酮类化合物和肉桂酸衍生物是蜂胶成分中的主要生物活性成分。根据本研究结果，对于轻度或中度疼痛的患者，建议使用蜂胶。当需要立即起效时，牙本质粘结剂可能是更好的选择。
