Mougeot Jean-Luc C, Stevens Craig B, Almon Kathryn G, Paster Bruce J, Lalla Rajesh V, Brennan Michael T, Mougeot Farah Bahrani
Carolinas Medical Center - Atrium Health, Charlotte, NC, USA.
The Forsyth Institute, Cambridge, MA, USA.
J Oral Microbiol. 2019 Mar 8;11(1):1586421. doi: 10.1080/20002297.2019.1586421. eCollection 2019.
Head and neck cancer (HNC) therapy often leads to caries development. Our goal was to characterize the oral microbiome of HNC patients who underwent radiation therapy (RT) at baseline (T0), and 6 (T6) and 18 (T18) months post-RT, and to determine if there was a relationship with increased caries. HOMI was used to determine the relative abundance (RA) of >600 bacterial species in oral samples of 31 HNC patients. The DMFS score was used to define patient groups with tooth decay increase (DMFS[+]) or no increase (DMFS[-]).A change in microbiome beta-diversity was observed at T6 and T18. The RA increased at T6 in both DMFS[+] and DMFS[-] groups. The RA of , the species often associated with caries in young children, decreased at T6 in the DMFS[-] group. The RA of the health-associated species, , decreased in the DMFS[+] group. The oral microbiome underwent significant changes in radiation-treated HNC patients, whether they developed caries or not. Caries rates were not associated with a difference in salivary flow reduction between DMFS[+] andDMFS[-] groups. Patients who develop caries might be more susceptible to certain species associated with oral disease or have fewer potentially protective oral species.
头颈癌（HNC）治疗常常会导致龋齿的发生。我们的目标是对31名头颈癌患者在基线期（T0）、放疗后6个月（T6）和18个月（T18）时接受放射治疗（RT）的口腔微生物群进行特征分析，并确定其与龋齿增加是否存在关联。使用HOMI来确定31名头颈癌患者口腔样本中600多种细菌的相对丰度（RA）。DMFS评分用于定义龋齿增加（DMFS[+]）或未增加（DMFS[-]）的患者组。在T6和T18时观察到微生物群β多样性的变化。在T6时，DMFS[+]组和DMFS[-]组的RA均增加。在DMFS[-]组中，常与幼儿龋齿相关的物种的RA在T6时下降。在DMFS[+]组中，与健康相关的物种的RA下降。无论是否发生龋齿，接受放疗的头颈癌患者的口腔微生物群都发生了显著变化。龋齿发生率与DMFS[+]组和DMFS[-]组之间唾液流量减少的差异无关。发生龋齿的患者可能更容易感染某些与口腔疾病相关的物种，或者具有较少的潜在保护性口腔物种。
Zotero 插件
