长松萝乙酸乙酯提取物对大鼠食管胃腺癌的作用1。
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats1.
作者信息
Mammadov Renad, Suleyman Bahadir, Altuner Durdu, Demirci Elif, Cetin Nihal, Yilmaz Adnan, Baykal Huseyin, Alpcan Hilal, Turumtay Emine Akyuz, Suleyman Halis
机构信息
Assistant Professor, Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Scientific, intellectual, conception and design of the study; manuscript preparation.
Assistant Professor, Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Conception and design of the study, manuscript preparation.
出版信息
Acta Cir Bras. 2019 Mar 18;34(3):e201900305. doi: 10.1590/s0102-865020190030000005.
PURPOSE
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).
METHODS
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.
RESULTS
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.
CONCLUSION
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
目的
研究此前未被研究过的长松萝乙酸乙酯提取物对N-甲基-N-亚硝基-N-亚硝基胍（MNNG）诱导的大鼠食管胃癌的影响。
方法
在MNNG诱导的大鼠食管胃腺癌模型中检测长松萝乙酸乙酯提取物的抗癌活性。长松萝乙酸乙酯提取物，以50和100mg/kg的口服剂量每日给药一次，持续六个月。MNNG在大鼠的食管和胃组织中诱导分化型和未分化型腺癌。
结果
从长松萝中获得的长松萝乙酸乙酯提取物可预防MNNG诱导的大鼠胃癌和食管癌发生。长松萝乙酸乙酯提取物在500、1000和2000mg/kg剂量下没有致死作用。50和100mg/kg的长松萝乙酸乙酯提取物具有显著的抗癌活性，表明它无毒且对癌组织具有选择性。
结论
该信息可能为未来长松萝乙酸乙酯提取物的临床应用提供线索。
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