Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 900953, USA.
Viruses. 2019 Mar 19;11(3):272. doi: 10.3390/v11030272.
Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Recent discoveries have demonstrated that tissue-resident lymphocyte subsets, comprised of innate lymphoid cells (ILCs) and unconventional T cells, have vital roles in the initiation of primary antiviral responses. Via direct and indirect mechanisms, ILCs and unconventional T cell subsets play a critical role in the ability of the immune system to mount an effective antiviral response through potent early cytokine production. In this review, we will summarize the current knowledge of tissue-resident lymphocytes during initial viral infection and evaluate their redundant or nonredundant contributions to host protection or virus-induced pathology.
感染受到组织驻留和循环免疫细胞的协同激活的限制。最近的发现表明，由固有淋巴样细胞（ILC）和非常规 T 细胞组成的组织驻留淋巴细胞亚群在启动原发性抗病毒反应中具有重要作用。通过直接和间接机制，ILC 和非常规 T 细胞亚群在免疫系统通过强大的早期细胞因子产生来产生有效的抗病毒反应的能力中发挥关键作用。在这篇综述中，我们将总结初始病毒感染期间组织驻留淋巴细胞的现有知识，并评估它们对宿主保护或病毒诱导的病理的冗余或非冗余贡献。
