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单倍型和芪类化合物诱导介导葡萄种间群体对霜霉病的抗性。

The Haplotype and Stilbenoid Induction Mediate Downy Mildew Resistance in a Grapevine Interspecific Population.

作者信息

Vezzulli Silvia, Malacarne Giulia, Masuero Domenico, Vecchione Antonella, Dolzani Chiara, Goremykin Vadim, Mehari Zeraye Haile, Banchi Elisa, Velasco Riccardo, Stefanini Marco, Vrhovsek Urska, Zulini Luca, Franceschi Pietro, Moser Claudio

机构信息

Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.

Ethiopian Institute of Agricultural Research, Addis Ababa, Ethiopia.

出版信息

Front Plant Sci. 2019 Mar 6;10:234. doi: 10.3389/fpls.2019.00234. eCollection 2019.

DOI:10.3389/fpls.2019.00234
PMID:30894868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6414455/
Abstract

The development of new resistant varieties to the oomycete (Berk.& Curt) is a promising way to combat downy mildew (DM), one of the major diseases threatening the cultivated grapevine ( L.). Taking advantage of a segregating population derived from "Merzling" (a mid-resistant hybrid) and "Teroldego" (a susceptible landrace), 136 F1 individuals were characterized by combining genetic, phenotypic, and gene expression data to elucidate the genetic basis of DM resistance and polyphenol biosynthesis upon infection. An improved consensus linkage map was obtained by scoring 192 microsatellite markers. The progeny were screened for DM resistance and production of 42 polyphenols. QTL mapping showed that DM resistance is associated with the herein named specific haplotype and it identified 46 novel metabolic QTLs linked to 30 phenolics-related parameters. A list of the 95 most relevant candidate genes was generated by specifically exploring the stilbenoid-associated QTLs. Expression analysis of 11 genes in genotypes displaying disparity in DM resistance level and stilbenoid accumulation revealed significant new candidates for the genetic control of stilbenoid biosynthesis and oligomerization. These overall findings emphasized that DM resistance is likely mediated by the major haplotype and stilbenoid induction.

摘要

培育对卵菌（Berk.& Curt）具有抗性的新品种是对抗霜霉病（DM）的一种有前景的方法，霜霉病是威胁栽培葡萄（L.）的主要病害之一。利用源自“梅尔茨林”（一种中度抗性杂交品种）和“泰罗德戈”（一种易感地方品种）的分离群体，通过结合遗传、表型和基因表达数据对136个F1个体进行特征分析，以阐明感染后霜霉病抗性和多酚生物合成的遗传基础。通过对192个微卫星标记进行评分，获得了一个改进的一致性连锁图谱。对后代进行霜霉病抗性和42种多酚产量的筛选。数量性状基因座（QTL）定位表明，霜霉病抗性与本文命名的特定单倍型相关，并鉴定出46个与30个酚类相关参数连锁的新代谢QTL。通过专门探索与芪类相关的QTL，生成了95个最相关候选基因的列表。对11个基因在霜霉病抗性水平和芪类积累存在差异的基因型中的表达分析，揭示了芪类生物合成和寡聚化遗传控制的重要新候选基因。这些总体发现强调，霜霉病抗性可能由主要单倍型和芪类诱导介导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/595cec2879be/fpls-10-00234-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/17312bdf7cb6/fpls-10-00234-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/2c84e9ff376e/fpls-10-00234-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/6dd804de3785/fpls-10-00234-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/e5dcdb0c3e54/fpls-10-00234-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/a31b3d8f951e/fpls-10-00234-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/595cec2879be/fpls-10-00234-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/17312bdf7cb6/fpls-10-00234-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/2c84e9ff376e/fpls-10-00234-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/6dd804de3785/fpls-10-00234-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/e5dcdb0c3e54/fpls-10-00234-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/a31b3d8f951e/fpls-10-00234-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c3/6414455/595cec2879be/fpls-10-00234-g0006.jpg

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