Lin Yng-Tzer Joseph, Chou Chein-Chin, Hsu Chin-Ying Stephen
Pediatric Dentistry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.
Faculty of Dentistry, National University of Singapore, Singapore.
J Dent Sci. 2017 Jun;12(2):179-184. doi: 10.1016/j.jds.2016.09.005. Epub 2017 Mar 22.
BACKGROUND/PURPOSE: Yakult is a well-known probiotic beverage consisting of a single live bacterial species, Shirota. However, the potential cariogenic/cariostatic effects of Yakult intake among children have not been studied yet. Hence, this study aimed to investigate the clinical effects of short-term Yakult intake on oral biofilm acidogenicity, cariogenic bacterial counts, and caries risk in children.
Eighteen children, 7-11 years of age, consumed standard Yakult daily for 7 days. Prior to and after intervention, functional oral biofilm acidogenicity characterized by the Stephan curve, and counts, and caries risk were determined.
Probiotic intervention demonstrated significant increase in minimum pH from 4.88 to 5.14 (P = 0.02), 18.2% reduction in area under the Stephen curve [area under the curve (AUC)], and 29.3% decrease in pH recovery time, although these two differences were not statistically significant. No difference was observed in and counts or caries risk after intervention (all P > 0.05). However, on subgroup analysis using "reduction of AUC" to separate "responders" from the "nonresponders", the significant cariostatic effects on oral biofilm acidogenicity, among "responders", were revealed by an increase in minimum pH (P = 0.005) and a reduction in pH recovery time (P = 0.003).
There may be a potential cariostatic effect of short-term Yakult intake in reducing functional biofilm acidogenicity in children with certain oral biofilm and risk profile. Further studies may be needed to validate this probiotic effect. Quality risk assessment may be critical prior to prescribing/recommending Yakult as an adjunct caries-preventive treatment for children.
背景/目的：养乐多是一种著名的益生菌饮料，由单一活细菌菌株——代田菌组成。然而，儿童摄入养乐多的潜在致龋/抑龋作用尚未得到研究。因此，本研究旨在探讨短期摄入养乐多对儿童口腔生物膜产酸性、致龋菌数量和龋齿风险的临床影响。
18名7至11岁的儿童每天饮用标准养乐多，持续7天。在干预前后，测定以斯蒂芬曲线为特征的功能性口腔生物膜产酸性、致龋菌数量和龋齿风险。
益生菌干预显示最低pH值从4.88显著增加至5.14（P = 0.02），斯蒂芬曲线下面积[曲线下面积（AUC）]减少18.2%，pH恢复时间减少29.3%，尽管这两个差异无统计学意义。干预后在致龋菌数量和龋齿风险方面未观察到差异（所有P > 0.05）。然而，在使用“AUC降低”将“反应者”与“无反应者”分开的亚组分析中，“反应者”中对口腔生物膜产酸性的显著抑龋作用表现为最低pH值增加（P = 0.005）和pH恢复时间缩短（P = 0.003）。
短期摄入养乐多可能对具有特定口腔生物膜和风险特征的儿童减少功能性生物膜产酸性具有潜在的抑龋作用。可能需要进一步研究来验证这种益生菌效应。在将养乐多作为儿童龋齿预防辅助治疗开处方/推荐之前，质量风险评估可能至关重要。
