Dr. LV Prasad Diagnostics and Research Laboratory, Khairtabad, Hyderabad, Telangana 500004, India.
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Gene. 2019 Jun 5;700:60-64. doi: 10.1016/j.gene.2019.03.032. Epub 2019 Mar 18.
Aquaporins (AQPs) are hydrophobic integral trans-membrane channel proteins implicated in cellular proliferation and water transport in various cancers. They compose a family of 13 different isoforms (25-34 kDa) in mammals that have been identified to date. These AQPs exhibit a unique pattern of tissue expression. Though they can be found in most tissues, they are mostly active in endothelial and epithelial tissues. In this review, the AQPs associated with female-specific cancers are comprehensively explored and their significant features are analysed. Recent findings revealing their role in female-specific carcinogenesis, especially cervical, ovarian, uterine/endometrial, and breast, will be also discussed.
水通道蛋白（AQP）是疏水性跨膜通道蛋白，与多种癌症中的细胞增殖和水转运有关。到目前为止，在哺乳动物中已鉴定出它们由 13 种不同的亚型（25-34 kDa）组成。这些 AQP 表现出独特的组织表达模式。虽然它们可以在大多数组织中找到，但它们主要在内皮和上皮组织中活跃。在这篇综述中，全面探讨了与女性特异性癌症相关的 AQP，并分析了它们的重要特征。还将讨论最近发现的它们在女性特异性致癌作用中的作用，特别是在宫颈癌、卵巢癌、子宫/子宫内膜癌和乳腺癌中。
