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丹麦银屑病的流行情况和特征:丹麦皮肤队列研究的结果。

Prevalence and characteristics of psoriasis in Denmark: findings from the Danish skin cohort.

机构信息

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.

出版信息

BMJ Open. 2019 Mar 20;9(3):e028116. doi: 10.1136/bmjopen-2018-028116.

Abstract

BACKGROUND

Wide-ranging psoriasis prevalence estimates have been reported, possibly due to methodological differences.

OBJECTIVES

To assess the prevalence of psoriasis in Denmark and to validate the use of questionnaire-based data to identify patients with psoriasis.

METHODS

We used data from the Danish Skin Cohort, a prospective cohort comprising general population adults, as well as patients with dermatologist-verified psoriasis and atopic dermatitis, respectively. The general population cohort was interviewed to assess the psoriasis prevalence in Denmark, and validation of the questions was performed.

RESULTS

From 3490 general population participants, 7.9% (n=275) were found to have self-reported psoriasis. Of these, 221 (prevalence 6.3%) had their disease diagnosed by a physician (the dermatologist-diagnosed prevalence was 4.3%), whereas 54 (prevalence 1.6%) were not diagnosed by a physician. A total of 176 (5%) had active psoriasis within the last 12 months. More than half of patients had at least one disease flare in the last 12 months, and 44.4% of patients with psoriasis had at least one family member with psoriasis, whereas this was only the case for 13.7% of non-psoriasis individuals. Validation of the psoriasis diagnosis yielded a high sensitivity and specificity, with little incremental value of limiting diagnoses to those diagnosed by a physician.

CONCLUSION

The lifetime-prevalence of self-reported psoriasis was found to be 7.9%, whereas the 1-year prevalence (ie, currently active psoriasis) was 5.0%. If used appropriately, questionnaire-based data may accurately identify patients with psoriasis.

摘要

背景

已报道了广泛的银屑病患病率估计值,这可能是由于方法学的差异。

目的

评估丹麦的银屑病患病率,并验证基于问卷的数据用于识别银屑病患者的效果。

方法

我们使用了丹麦皮肤队列的数据,该队列是一个由普通人群成年人以及分别经皮肤科医生确诊的银屑病和特应性皮炎患者组成的前瞻性队列。对普通人群队列进行了访谈以评估丹麦的银屑病患病率,并对这些问题进行了验证。

结果

在 3490 名普通人群参与者中,发现有 7.9%(n=275)自我报告患有银屑病。其中,221 名(患病率 6.3%)的疾病由医生诊断(皮肤科医生诊断的患病率为 4.3%),而 54 名(患病率 1.6%)未被医生诊断。共有 176 名(5%)在过去 12 个月内患有活动性银屑病。超过一半的患者在过去 12 个月内至少有一次疾病发作,并且 44.4%的银屑病患者至少有一位家族成员患有银屑病,而在非银屑病患者中这一比例仅为 13.7%。银屑病诊断的验证具有较高的敏感性和特异性,将诊断仅限于经医生诊断的诊断的效果几乎没有增量价值。

结论

自我报告的银屑病终生患病率为 7.9%,而 1 年患病率(即目前活动性银屑病)为 5.0%。如果使用得当,基于问卷的数据可能会准确地识别出银屑病患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/6475143/6eadf2f17727/bmjopen-2018-028116f01.jpg

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