Tumor is a multifactorial sickness and consequently can be viably overwhelmed by a multi-constituently remedial strategy. Herbal extracts shows the example of such stratagem. However, less research have been carried out till date that portray the effect of different extraction techniques on the phyto compounds profile of plant extracts and its effect on anticancer activity. Cucumber ( L.) is a member of the Cucurbitaceae family like melon, squash and pumpkins. It is a popular vegetable harvest in Indian customary medicine since olden times. It has potential lipid lowering and antioxidant activity and antidiabetic. In the present study, we have evaluated the anticancer prospective of methanolic and acetone extracts of (CSME) and (CSAE). Reported results show that (CSME) is rich in bioactive compounds shown anticancer activity with Cell lines of (IC50) with MCF 715.6 ± 1.3 and HeLa 28.2 ± 1. This study on the presence of cytotoxic from the L.), which have been further used in herbal formulations study as an anticancer activity. Our conclusion support additional in-depth study of this pharmacologic activity as an malignant tumor agent.