Tuama Ammar Adnan, Mohammed Arif Ahmed
University of Diyala, Ministry of Higher Education and Scientific Research, College of Basic Education, Iraq.
Center of Excellence in Biotechnology Research, King Saud University, Saudi Arabia.
Saudi J Biol Sci. 2019 Mar;26(3):600-604. doi: 10.1016/j.sjbs.2018.07.012. Epub 2018 Jul 31.
Tumor is a multifactorial sickness and consequently can be viably overwhelmed by a multi-constituently remedial strategy. Herbal extracts shows the example of such stratagem. However, less research have been carried out till date that portray the effect of different extraction techniques on the phyto compounds profile of plant extracts and its effect on anticancer activity. Cucumber ( L.) is a member of the Cucurbitaceae family like melon, squash and pumpkins. It is a popular vegetable harvest in Indian customary medicine since olden times. It has potential lipid lowering and antioxidant activity and antidiabetic. In the present study, we have evaluated the anticancer prospective of methanolic and acetone extracts of (CSME) and (CSAE). Reported results show that (CSME) is rich in bioactive compounds shown anticancer activity with Cell lines of (IC50) with MCF 715.6 ± 1.3 and HeLa 28.2 ± 1. This study on the presence of cytotoxic from the L.), which have been further used in herbal formulations study as an anticancer activity. Our conclusion support additional in-depth study of this pharmacologic activity as an malignant tumor agent.
肿瘤是一种多因素疾病，因此可以通过多成分治疗策略有效地攻克。草药提取物就展示了这种策略。然而，迄今为止，关于不同提取技术对植物提取物中植物化合物谱的影响及其对抗癌活性的影响的研究较少。黄瓜（L.）是葫芦科的一员，与甜瓜、南瓜和西葫芦一样。自古以来，它就是印度传统医学中一种受欢迎的蔬菜作物。它具有潜在的降血脂、抗氧化活性和抗糖尿病作用。在本研究中，我们评估了黄瓜甲醇提取物（CSME）和丙酮提取物（CSAE）的抗癌潜力。报告结果表明，CSME富含生物活性化合物，对MCF 7细胞系（IC50为15.6±1.3）和HeLa细胞系（IC50为28.2±1）显示出抗癌活性。本研究关于黄瓜中细胞毒性物质的存在，这些物质已进一步用于草药制剂研究作为抗癌活性成分。我们的结论支持对这种作为恶性肿瘤药物的药理活性进行更多深入研究。
