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人类淋巴细胞对细菌成分的多克隆抗体形成。

Polyclonal antibody formation of human lymphocytes to bacterial components.

作者信息

Räsänen L, Lehto M, Jokinen I, Leinikki P

出版信息

Immunology. 1986 Aug;58(4):577-81.

PMID:3089918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453112/
Abstract

The capacity of various bacterial components to induce antibody formation in human lymphocyte cultures was studied in the present investigation. Antibody levels were determined by an enzyme-linked immunosorbent assay (ELISA). Lipopolysaccharide (LPS), bacterial cell walls (CW, isolated from Bacillus subtilis and Staphylococcus aureus Wood 46) and peptidoglycans (PG) appeared to stimulate IgM, IgG and IgA secretion, whereas lysozyme-solubilized PG and teichoic acids (TA) were ineffective. Also, umbilical cord blood lymphocytes produced IgM after stimulation with LPS, CW and PG. Coculture experiments with purified lymphocytes and monocytes indicated that B-cell differentiation was dependent on both T cells and monocytes, and that T-cell derived factors could derived factors could partially substitute for T cells.

摘要

本研究探讨了多种细菌成分在人淋巴细胞培养物中诱导抗体形成的能力。通过酶联免疫吸附测定法（ELISA）测定抗体水平。脂多糖（LPS）、细菌细胞壁（CW，从枯草芽孢杆菌和金黄色葡萄球菌Wood 46中分离）和肽聚糖（PG）似乎能刺激IgM、IgG和IgA分泌，而溶菌酶溶解的PG和磷壁酸（TA）则无效。此外，脐带血淋巴细胞在用LPS、CW和PG刺激后产生IgM。纯化淋巴细胞和单核细胞的共培养实验表明，B细胞分化依赖于T细胞和单核细胞，并且T细胞衍生因子可以部分替代T细胞。

相似文献

1
Polyclonal antibody formation of human lymphocytes to bacterial components.人类淋巴细胞对细菌成分的多克隆抗体形成。
Immunology. 1986 Aug;58(4):577-81.
2
Polyclonal response of human lymphocytes to bacterial cell walls, peptidoglycans and teichoic acids.人类淋巴细胞对细菌细胞壁、肽聚糖和磷壁酸的多克隆反应。
Immunology. 1982 Jul;46(3):481-6.
3
Immediate burn wound excision restores antibody synthesis to bacterial antigen.立即进行烧伤创面切除可恢复针对细菌抗原的抗体合成。
J Surg Res. 1996 Jun;63(1):157-62. doi: 10.1006/jsre.1996.0240.
4
Cell walls, peptidoglycans, and teichoic acids of gram-positive bacteria as polyclonal inducers and immunomodulators of proliferative and lymphokine responses of human B and T lymphocytes.革兰氏阳性菌的细胞壁、肽聚糖和磷壁酸作为人B淋巴细胞和T淋巴细胞增殖及淋巴因子反应的多克隆诱导剂和免疫调节剂。
Infect Immun. 1981 Dec;34(3):712-7. doi: 10.1128/iai.34.3.712-717.1981.
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Polyclonal activation of immunoglobulin secretion in B lymphocytes induced by staphylococcal peptidoglycan.葡萄球菌肽聚糖诱导B淋巴细胞中免疫球蛋白分泌的多克隆激活。
J Immunol. 1980 Dec;125(6):2478-83.
6
Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing Staphylococcus aureus.表面免疫球蛋白参与蛋白A与人类B细胞的相互作用，以及含蛋白A的金黄色葡萄球菌诱导的B细胞增殖的触发过程。
J Immunol. 1981 Oct;127(4):1307-13.
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Staphylococcus aureus Cowan I-induced immunoglobulin production in human cord blood lymphocytes.金黄色葡萄球菌考恩I诱导人脐血淋巴细胞产生免疫球蛋白
J Immunol. 1980 Jul;125(1):411-3.
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B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes.人类脐带血淋巴细胞中的B细胞分化及免疫调节性T细胞功能
J Clin Invest. 1980 Aug;66(2):383-8. doi: 10.1172/JCI109867.
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[Immunity of the skin--infection and percutaneous immunization of rabbits with E. coli ATCC 13676].[皮肤免疫——用大肠杆菌ATCC 13676对家兔进行感染和经皮免疫]
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Apr;259(2):252-67.
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Functional maturity of cord blood B lymphocytes: Staphylococcus aureus Cowan 1 induces IgG secretion in the human neonate.脐血B淋巴细胞的功能成熟：金黄色葡萄球菌考恩1株诱导人类新生儿分泌IgG
Clin Exp Immunol. 1983 Sep;53(3):703-8.

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本文引用的文献

1
Mitogenic responsiveness of mouse, rat and human lymphocytes to Staphylococcus aureus cell wall, teichoic acid, and peptidoglycan.小鼠、大鼠和人类淋巴细胞对金黄色葡萄球菌细胞壁、磷壁酸和肽聚糖的促有丝分裂反应性。
Int Arch Allergy Appl Immunol. 1980;63(4):383-95. doi: 10.1159/000232654.
2
T-cell-dependent and independent plasma cell differentiation induced by Escherichia coli Lipopolysaccharide in human peripheral blood lymphocytes.大肠杆菌脂多糖诱导人外周血淋巴细胞中T细胞依赖性和非依赖性浆细胞分化
Clin Immunol Immunopathol. 1981 Mar;18(3):309-21. doi: 10.1016/0090-1229(81)90124-0.
3
Induction of human immunoglobulin secretion. I. Synergistic effect of B cell mitogen Cowan I plus T cell mitogens or factors.人免疫球蛋白分泌的诱导。I. B细胞促有丝分裂原考恩I与T细胞促有丝分裂原或因子的协同作用。
J Immunol. 1981 Sep;127(3):1044-7.
4
Polyclonal activation of human peripheral blood B lymphocytes by formaldehyde-fixed Salmonella paratyphi B. I. Immunoglobulin production without DNA synthesis.甲醛固定的副伤寒乙杆菌对人外周血B淋巴细胞的多克隆激活。I. 无DNA合成的免疫球蛋白产生。
J Exp Med. 1981 Feb 1;153(2):365-74. doi: 10.1084/jem.153.2.365.
5
Cell walls, peptidoglycans, and teichoic acids of gram-positive bacteria as polyclonal inducers and immunomodulators of proliferative and lymphokine responses of human B and T lymphocytes.革兰氏阳性菌的细胞壁、肽聚糖和磷壁酸作为人B淋巴细胞和T淋巴细胞增殖及淋巴因子反应的多克隆诱导剂和免疫调节剂。
Infect Immun. 1981 Dec;34(3):712-7. doi: 10.1128/iai.34.3.712-717.1981.
6
Synthesis of IgM, IgG and IgA in rheumatoid arthritis.类风湿关节炎中IgM、IgG和IgA的合成
Ann Rheum Dis. 1982 Dec;41(6):607-11. doi: 10.1136/ard.41.6.607.
7
Staphylococcal peptidoglycan: T-cell-dependent mitogen and relatively T-cell-independent polyclonal B-cell activator of human lymphocytes.葡萄球菌肽聚糖：人淋巴细胞的T细胞依赖性丝裂原及相对T细胞非依赖性多克隆B细胞激活剂。
Infect Immun. 1983 Jan;39(1):290-6. doi: 10.1128/iai.39.1.290-296.1983.
8
Human B cell activation in vitro: augmentation and suppression by monocytes of the immunoglobulin production induced by various B cell stimulants.人B细胞的体外激活：单核细胞对各种B细胞刺激剂诱导的免疫球蛋白产生的增强和抑制作用。
J Immunol. 1981 Feb;126(2):529-37.
9
Characterization of the subpopulations of human peripheral blood B lymphocytes which react to staphylococcus aureus Cowan I and T-cell help.对与金黄色葡萄球菌考恩I反应的人类外周血B淋巴细胞亚群及T细胞辅助作用的表征
Cell Immunol. 1983 May;78(1):130-43. doi: 10.1016/0008-8749(83)90266-6.
10
Separate signals for human B cell proliferation and differentiation in response to Staphylococcus aureus: evidence for a two-signal model of B cell activation.金黄色葡萄球菌诱导人B细胞增殖和分化的独立信号：B细胞激活双信号模型的证据
J Immunol. 1982 Jul;129(1):97-102.