Garg Pankaj
Department of Chemistry, GLA University, Mathura, Uttar Pradesh, India.
J Cancer Res Ther. 2019 Mar;15(Supplement):S1-S10. doi: 10.4103/jcrt.JCRT_218_18.
A new modality of targeting therapeutic drugs based on the use of bacteriophage (virus), as an emerging tool for specific targeting and for vaccine development, has been an area of interest for genetic and cancer research. The approach is based on genetic manipulation and modification in the chemical structure of a filamentous bacteriophage that facilitates its application not only for in vivo imaging but also for therapeutic purpose, as a gene delivery vehicle, as drug carriers, and also as an immunomodulatory agent. Filamentous bacteriophage on account of its high surface holding ability with adaptable genetic engineering properties can effectively be used in loading of chemical and genetic drugs specifically on to the targeted lesion location. Moreover, the specific peptides/proteins exhibited on the phage surface can be applied directly as self-navigating drug delivery nanovehicles. The present review article has been framed with an objective to summarize the importance of bacteriophage in phage cancer therapy and to understand the possible future prospective of this approach in developing new tools for biotechnological and genetic research, especially in phage -mediated cancer therapy. Importantly, the peptides or proteins emerging from the surface of a nano carrier will make the expense of such peptides economically more effective as compared to other immunological tools, and this seems to be a potential approach for developing a new nanodrug carrier platform.
基于噬菌体（病毒）的靶向治疗药物新方法，作为一种用于特异性靶向和疫苗开发的新兴工具，一直是基因和癌症研究的关注领域。该方法基于对丝状噬菌体化学结构的基因操作和修饰，这不仅便于其用于体内成像，还可用于治疗目的，如作为基因传递载体、药物载体以及免疫调节剂。丝状噬菌体因其具有高表面容纳能力和可适应的基因工程特性，能够有效地将化学和基因药物特异性地加载到靶向病变部位。此外，噬菌体表面展示的特定肽/蛋白质可直接用作自动导航药物递送纳米载体。本综述文章旨在总结噬菌体在噬菌体癌症治疗中的重要性，并了解该方法在开发生物技术和基因研究新工具，特别是噬菌体介导的癌症治疗方面可能的未来前景。重要的是，与其他免疫工具相比，纳米载体表面出现的肽或蛋白质将使此类肽在经济上更具成本效益，这似乎是开发新型纳米药物载体平台的一种潜在方法。
