Hsu S M, Huang L C, Hsu P L, Ge Z H, Ho Y S, Cuttita F, Mulshine J
J Natl Cancer Inst. 1986 Aug;77(2):363-70.
A group of monoclonal antibodies was shown to react with glycoconjugates containing a sugar sequence--lacto-N-fucopentaose III (LNF-III)--in granulocytes and in some normal nonlymphoid cells. The antibodies including anti-Leu M1, anti-My-1, WGHS 29-1, 534F-8, and 538F-12 of the immunoglobulin M-type were used to study the biochemical properties of LNF-III antigens in granulocytes, interdigitating reticulum cells, and neoplastic cells of Hodgkin's disease. In contrast to the presence of an abundant LNF-III glycolipid in granulocytes, the Hodgkin's neoplastic cells had no LNF-III glycolipid or contained only minimal amounts; however, both LNF-III glycoconjugates isolated from Hodgkin's neoplastic cells and interdigitating reticulum cells appeared to be a similar, if not an identical, 150,000-molecular-weight glycoprotein. The neoplastic cells in Hodgkin's disease appeared to show a biochemical property more closely related to interdigitating reticulum cells than any other cells in the monocyte-granulocyte-histiocyte system.
已证明一组单克隆抗体可与粒细胞及某些正常非淋巴细胞中含乳糖-N-岩藻五糖III（LNF-III）糖序列的糖缀合物发生反应。包括免疫球蛋白M型的抗-Leu M1、抗-My-1、WGHS 29-1、534F-8和538F-12在内的这些抗体，被用于研究粒细胞、交错突网状细胞和霍奇金病肿瘤细胞中LNF-III抗原的生化特性。与粒细胞中存在丰富的LNF-III糖脂不同，霍奇金病肿瘤细胞没有LNF-III糖脂或仅含有极少量；然而，从霍奇金病肿瘤细胞和交错突网状细胞中分离出的LNF-III糖缀合物似乎是一种相似（即便不是相同）的150,000分子量糖蛋白。霍奇金病中的肿瘤细胞似乎显示出一种与交错突网状细胞比单核细胞-粒细胞-组织细胞系统中的任何其他细胞更密切相关的生化特性。
