昼夜节律基因与心肌梗死的关系
The Impact of the Circadian Genes and on Myocardial Infarction.
作者信息
Škrlec Ivana, Milić Jakov, Steiner Robert
机构信息
Histology, Genetics, Cellular, and Molecular Biology Laboratory, Department of Biology and Chemistry, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, HR-31000 Osijek, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, HR-31000 Osijek, Croatia.
出版信息
J Clin Med. 2020 Feb 10;9(2):484. doi: 10.3390/jcm9020484.
The circadian rhythm regulates various physiological mechanisms, and its disruption can promote many disorders. Disturbance of endogenous circadian rhythms enhances the chance of myocardial infarction (MI), showing that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was performed on 1057 participants. It was hypothesized that the polymorphisms of one nucleotide (SNP) in three circadian clock genes (, , and ) could be associated with MI. Statistically significant differences, estimated by the Chi-square test, were found in the distribution of alleles and genotypes between MI and no-MI groups of the (rs6811520 and rs13124436) and (rs3789327 and rs12363415) genes. According to the results of the present study, the polymorphisms in the and genes could be related to MI.
昼夜节律调节各种生理机制，其紊乱会引发多种疾病。内源性昼夜节律的紊乱会增加心肌梗死（MI）的发生几率，这表明昼夜节律时钟基因在该疾病的发病过程中可能具有关键作用。本病例对照研究共纳入1057名参与者。研究假设三个昼夜节律时钟基因（、和）中的单核苷酸多态性（SNP）可能与心肌梗死有关。通过卡方检验估计，在（rs6811520和rs13124436）和（rs3789327和rs12363415）基因的心肌梗死组和非心肌梗死组之间，等位基因和基因型的分布存在统计学显著差异。根据本研究结果，和基因中的多态性可能与心肌梗死有关。
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