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MiRNA-338-3p regulates cervical cancer cells proliferation by targeting MACC1 through MAPK signaling pathway.miRNA-338-3p 通过 MAPK 信号通路靶向调控 MACC1 抑制宫颈癌的增殖。
Eur Rev Med Pharmacol Sci. 2017 Dec;21(23):5342-5352. doi: 10.26355/eurrev_201712_13919.
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miR-338-3p inhibits the invasion of renal cell carcinoma by downregulation of ALK5.微小RNA-338-3p通过下调激活素受体样激酶5抑制肾细胞癌的侵袭。
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Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer.结肠癌转移相关蛋白1：一种用于结直肠癌转移和预后的有前景的生物标志物。
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MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation.微小RNA-338-3p调控神经元成熟并抑制胶质母细胞瘤增殖。
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Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.组织和血液中MACC1水平升高可识别出高危结肠腺瘤患者。
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Metastasis associated in colon cancer 1 (MACC1) promotes growth and metastasis processes of colon cancer cells.结肠癌转移相关蛋白1（MACC1）促进结肠癌细胞的生长和转移过程。
Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2825-34.
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Mir-338-3p Inhibits Malignant Biological Behaviors of Glioma Cells by Targeting MACC1 Gene.Mir-338-3p通过靶向MACC1基因抑制胶质瘤细胞的恶性生物学行为。
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微小RNA-338-3p通过靶向结肠癌转移相关蛋白1调控SW480细胞的增殖、凋亡和迁移。

miR-338-3p regulates the proliferation, apoptosis and migration of SW480 cells by targeting MACC1.

作者信息

Lu Mingliang, Huang Hua, Yang Jinhui, Li Jun, Zhao Gongfang, Li Weihua, Li Xinhua, Liu Guobin, Wei Li, Shi Baoping, Zhao Chunping, Fu Yan

机构信息

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China.

Department of Gastroenterology, No. 1 People's Hospital of Dali City, Dali, Yunnan 671000, P.R. China.

出版信息

Exp Ther Med. 2019 Apr;17(4):2807-2814. doi: 10.3892/etm.2019.7260. Epub 2019 Feb 12.

DOI:10.3892/etm.2019.7260
PMID:30906469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6425231/
Abstract

The mortality and incidence rates of colorectal cancer (CRC) vary widely worldwide. miR-338-3p inhibits tumor cell proliferation in several types of cancer, however, the role of miR-338-3p on CRC remains unknown. The aim of the current study was to investigate the cellular function of miRNA-338-3p (miR-338-3p) in CRC, the malignant behavior of CRC cells and the interaction between miR-338-3p and metastasis-associated in colon cancer-1 (MACC1). miR-338-3p expression was significantly decreased in CRC tissue compared with adjacent normal tissue. In the CRC cell line SW480, miR-338-3p overexpression suppressed cell proliferation and migration and induced G1/S cell cycle arrest and apoptosis. By contrast, miR-338-3p knockdown significantly enhanced cell proliferation and migration, and suppressed G1/S cell cycle arrest and apoptosis. Furthermore, the dual-luciferase reporter assay confirmed MACC1 as a direct target of miR-338-3p. In addition, miR-338-3p overexpression reduced the level of MACC1 protein expression and MACC1 expression was significantly upregulated in CRC tissue samples. MACC1 siRNA significantly reduced CRC cell proliferation and migration, whilst cell apoptosis was significantly increased. In conclusion, miR-338-3p expression was decreased in CRC. miR-338-3p regulated the proliferation, apoptosis and migration of CRC cells by targeting MACC1.

摘要

结直肠癌（CRC）的死亡率和发病率在全球范围内差异很大。miR-338-3p在几种癌症中抑制肿瘤细胞增殖，然而，miR-338-3p在结直肠癌中的作用尚不清楚。本研究的目的是探讨miRNA-338-3p（miR-338-3p）在结直肠癌中的细胞功能、结直肠癌细胞的恶性行为以及miR-338-3p与结肠癌转移相关蛋白1（MACC1）之间的相互作用。与相邻正常组织相比，结直肠癌组织中miR-338-3p表达显著降低。在结直肠癌细胞系SW480中，miR-338-3p过表达抑制细胞增殖和迁移，并诱导G1/S期细胞周期阻滞和凋亡。相反，miR-338-3p敲低显著增强细胞增殖和迁移，并抑制G1/S期细胞周期阻滞和凋亡。此外，双荧光素酶报告基因检测证实MACC1是miR-338-3p的直接靶点。此外，miR-338-3p过表达降低了MACC1蛋白表达水平，且MACC1在结直肠癌组织样本中的表达显著上调。MACC1 siRNA显著降低结直肠癌细胞增殖和迁移，同时细胞凋亡显著增加。总之，结直肠癌中miR-338-3p表达降低。miR-338-3p通过靶向MACC1调节结直肠癌细胞的增殖、凋亡和迁移。