Liu Jin, Nazaran Amin, Ma Yajun, Chen Haimei, Zhu Yanchun, Du Jiang, Li Shaolin, Zhou Quan, Zhao Yinghua
Department of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics, Guangdong Province), 183 Zhongshan Da Dao Xi, Guangzhou 510630, China.
Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Biomed Res Int. 2019 Feb 18;2019:8597423. doi: 10.1155/2019/8597423. eCollection 2019.
The collagen density is not detected in the patellar tendon (PT), posterior cruciate ligament (PCL), and anterior cruciate ligament (ACL) in clinic. We assess the technical feasibility of three-dimension multiecho fat saturated ultrashort echo time cones (3D FS-UTE-Cones) acquisitions for single- and bicomponent T2⁎ analysis of bound and free water pools in PT, PCL, and ACL in clinic. The knees of five healthy volunteers and six knee joint samples from cadavers were scanned via 3D multiecho FS-UTE-Cones acquisitions on a clinical scanner. Single-component fitting of T2⁎ and bicomponent fitting of short T2⁎ (T2⁎), long T2⁎ (T2⁎), short T2⁎ fraction (Frac_), and long T2⁎ fraction (Frac_) were performed within tendons and ligaments. Our results showed that biexponential fitting was superior to single-exponential fitting in PT, PCL, and ACL. For knee joint samples, there was no statistical difference among all data in PT, PCL, and ACL. For volunteers, all parameters of bicomponent fitting were statistically different across PT, PCL, and ACL, except for T2⁎, T2⁎, and T2⁎ resulting in flawed measurements due to the magic angle effect. 3D multiecho FS-UTE-Cones acquisition allows high resolution T2⁎ mapping in PT, PCL, and ACL of keen joint samples and PT and PCL of volunteers. The T2⁎ values and their fractions can be characterized by bicomponent T2⁎ analysis that is superior to single-component T2⁎ analysis, except for ACL of volunteers.
在临床上，髌腱（PT）、后交叉韧带（PCL）和前交叉韧带（ACL）中未检测到胶原密度。我们评估了临床中用于对PT、PCL和ACL中结合水和自由水池进行单组分和双组分T2⁎分析的三维多回波脂肪饱和超短回波时间锥体（3D FS - UTE - Cones）采集的技术可行性。对五名健康志愿者的膝盖以及来自尸体的六个膝关节样本在临床扫描仪上通过3D多回波FS - UTE - Cones采集进行扫描。在肌腱和韧带内进行T2⁎的单组分拟合以及短T2⁎（T2⁎）、长T2⁎（T2⁎）、短T2⁎分数（Frac_）和长T2⁎分数（Frac_）的双组分拟合。我们的结果表明，在PT、PCL和ACL中，双指数拟合优于单指数拟合。对于膝关节样本，PT、PCL和ACL中的所有数据之间没有统计学差异。对于志愿者，双组分拟合的所有参数在PT、PCL和ACL之间存在统计学差异，但由于魔角效应，T2⁎、T2⁎和T2⁎的测量存在缺陷。3D多回波FS - UTE - Cones采集能够在膝关节样本的PT、PCL和ACL以及志愿者的PT和PCL中进行高分辨率T2⁎成像。除了志愿者的ACL外，T2⁎值及其分数可以通过优于单组分T2⁎分析的双组分T2⁎分析来表征。
