da Silva Andre Paes B, Alluri Leela Subhashini C, Bissada Nabil F, Gupta Sanjay
Department of Periodontics, Case Western Reserve University, School of Dental Medicine Cleveland 44106, Ohio.
Department of Urology, Case Western Reserve University, School of Dental Medicine Cleveland 44106, Ohio.
Am J Clin Exp Urol. 2019 Feb 18;7(1):1-10. eCollection 2019.
Chronic inflammation and infections are associated with increased risk of prostate cancer development. There is considerable evidence that proves the interrelationship between bacterial/viral infections and carcinogenesis. Periodontitis is a chronic inflammatory disease triggered by gram-negative anaerobic bacteria. In this narrative review, we investigate the relationship between periodontal disease and prostate cancer by reviewing previous studies of the association and possible mechanisms that may explain this link.
A comprehensive search for articles published was performed using the key words, "periodontal disease", "prostate disease", "prostate cancer", "prostatic inflammation". Thorough reviews of each study were conducted and assessed for eligibility, and data was summarized.
The role of inflammatory responses in the prostate as drivers of malignancy appears to be predisposed by periodontal pathogens and/or periodontitis inflammatory mediators.
Periodontal diseases might be associated with prostate cancer. However, the mechanism(s) explaining this relationship remains unclear and requires further elucidation.
慢性炎症和感染与前列腺癌发生风险增加相关。有大量证据证明细菌/病毒感染与致癌作用之间存在相互关系。牙周炎是一种由革兰氏阴性厌氧菌引发的慢性炎症性疾病。在这篇叙述性综述中，我们通过回顾以往关于两者关联的研究以及可能解释这种联系的机制，来探究牙周疾病与前列腺癌之间的关系。
使用关键词“牙周疾病”“前列腺疾病”“前列腺癌”“前列腺炎症”对已发表的文章进行全面检索。对每项研究进行深入审查并评估其 eligibility，然后汇总数据。
前列腺中的炎症反应作为恶性肿瘤驱动因素的作用似乎是由牙周病原体和/或牙周炎炎症介质预先决定的。
牙周疾病可能与前列腺癌有关。然而，解释这种关系的机制仍不清楚，需要进一步阐明。
