Guizhou Engineering Center for Innovative Traditional Chinese Medicine and Ethnic Medicine, Guizhou University, Guiyang, P. R. China.
College of Pharmacy, Guizhou University of Chinese Medicine, Guiyang, P. R. China.
Nat Prod Res. 2020 Sep;34(18):2621-2625. doi: 10.1080/14786419.2018.1544979. Epub 2019 Mar 25.
The chemical composition and biological activities of the essential oil (EO) from the rhizomes of Diels were reported for the first time. Forty-five compounds were identified, and represented 95.7% of the total composition of the EO. The predominant components of the EO were -phellandrene (24.0%), sabinene (17.3%), -pinene (11.4%), geranyl linalool (8.6%), terpinen-4-ol (8.3%), -pinene (5.6%) and crypton (4.5%). The EO revealed a weak DPPH and ABTS radical-scavenging activity. The EO exhibited significant antimicrobial activity with the inhibition zones (12.86-24.62 mm) and MIC (0.78-3.12 mg/mL) against , , , , . The EO showed significant cytotoxicity against human leukemic (K562), lung cancer (A549) and prostatic carcinoma (PC-3) cell lines with the IC values of 29.67, 48.87 and 86.05 μg/mL, respectively. Thus, the EO could be regarded as a bioactive natural product with potential for utilization in the cosmetic and pharmaceutical industry.
首次报道了白菖根茎精油(EO)的化学成分和生物活性。鉴定出 45 种化合物,占 EO 总成分的 95.7%。EO 的主要成分是 -柠檬烯(24.0%)、柠檬烯(17.3%)、-蒎烯(11.4%)、香叶基芳樟醇(8.6%)、萜品-4-醇(8.3%)、-蒎烯(5.6%)和隐酮(4.5%)。EO 显示出微弱的 DPPH 和 ABTS 自由基清除活性。EO 对 、 、 、 、 具有显著的抗菌活性,抑菌圈(12.86-24.62 毫米)和 MIC(0.78-3.12 毫克/毫升)。EO 对人白血病(K562)、肺癌(A549)和前列腺癌(PC-3)细胞系表现出显著的细胞毒性,IC 值分别为 29.67、48.87 和 86.05 μg/mL。因此,EO 可以被视为一种具有潜在利用价值的生物活性天然产物,可用于化妆品和制药行业。