Paschinger Katharina, Yan Shi, Wilson Iain B H
Department für Chemie, Universität für Bodenkultur, Wien, Austria.
Institut für Parasitologie, Veterinärmedizinische Universität, Wien, Austria.
Front Mol Biosci. 2019 Mar 12;6:9. doi: 10.3389/fmolb.2019.00009. eCollection 2019.
is a genetically well-studied model nematode or "worm"; however, its N-glycomic complexity is actually baffling and still not completely unraveled. Some features of its N-glycans are, to date, unique and include bisecting galactose and up to five fucose residues associated with the asparagine-linked ManGlcNAc core; the substitutions include galactosylation of fucose, fucosylation of galactose and methylation of mannose or fucose residues as well as phosphorylcholine on antennal (non-reducing) acetylglucosamine. Only some of these modifications are shared with various other nematodes, while others have yet to be detected in any other species. Thus, can be used as a model for some aspects of N-glycan function, but its glycome is far from identical to those of other organisms and is actually far from simple. Possibly the challenges of its native environment, which differ from those of parasitic or necromenic species, led to an anatomically simple worm possessing a complex glycome.
是一种在遗传学上研究充分的模式线虫或“蠕虫”；然而，其N - 糖组的复杂性实际上令人困惑，仍未完全阐明。迄今为止，其N - 聚糖的一些特征是独特的，包括与天冬酰胺连接的ManGlcNAc核心相关的平分半乳糖和多达五个岩藻糖残基；这些取代包括岩藻糖的半乳糖基化、半乳糖的岩藻糖基化、甘露糖或岩藻糖残基的甲基化以及触角（非还原）乙酰葡糖胺上的磷酸胆碱。这些修饰中只有一些与其他各种线虫共有，而其他一些修饰在任何其他物种中尚未被检测到。因此，可作为N - 聚糖功能某些方面的模型，但它的糖组与其他生物体的糖组远不相同，实际上也远非简单。可能其原生环境的挑战与寄生或尸食性物种不同，导致这种解剖结构简单的蠕虫拥有复杂的糖组。
