Araki S, Aono H, Murata K
Br J Ind Med. 1986 Sep;43(9):636-41. doi: 10.1136/oem.43.9.636.
To investigate the effects of calcium disodium ethylenediamine tetra-acetate (CaEDTA) on the urinary excretion, erythrocyte, and plasma concentrations and exposure indicators of seven heavy metals, CaEDTA was administered by intravenous infusion to 20 workers exposed to lead, zinc, and copper. The workers' blood lead concentrations ranged from 22 to 59 micrograms/dl (mean 38 micrograms/dl (1.8 mumol/l]. The 24 hour urinary excretion of metals after CaEDTA administration (mobilisation yield) was on average 13 times the background excretion for lead, 11 times for zinc, 3.8 times for manganese, 3.4 times for cadmium, 1.3 times for copper, and 1.1 times for chromium; no significant increase was found for mercury. The mobilisation yield of lead (MPb) was significantly correlated with whole blood and erythrocyte concentrations and the urinary excretion of lead but not with its plasma concentration; similarly, the mobilisation yield of cadmium was significantly correlated with its erythrocyte concentration. In addition, MPb was significantly correlated with intra-erythrocytic enzyme delta-aminolaevulinic acid dehydratase activity and urinary coproporphyrin excretion. The relation between the mobilisation yield of heavy metals and their body burden (and toxic signs) is discussed in the light of these findings.
为研究乙二胺四乙酸二钠钙（CaEDTA）对七种重金属的尿排泄、红细胞和血浆浓度以及暴露指标的影响，对20名接触铅、锌和铜的工人进行了静脉输注CaEDTA。这些工人的血铅浓度范围为22至59微克/分升（平均38微克/分升（1.8微摩尔/升））。CaEDTA给药后24小时金属的尿排泄量（动员率）平均为铅背景排泄量的13倍、锌的11倍、锰的3.8倍、镉的3.4倍、铜的1.3倍和铬的1.1倍；汞未发现显著增加。铅的动员率（MPb）与全血和红细胞浓度以及铅的尿排泄量显著相关，但与血浆浓度无关；同样，镉的动员率与其红细胞浓度显著相关。此外，MPb与红细胞内酶δ-氨基乙酰丙酸脱水酶活性和尿中粪卟啉排泄量显著相关。根据这些发现，讨论了重金属动员率与其体内负荷（和中毒体征）之间的关系。
