血浆中铅的测定及其与红细胞中铅关系的研究。
Determination of lead in plasma and studies on its relationship to lead in erythrocytes.
作者信息
deSilva P E
出版信息
Br J Ind Med. 1981 Aug;38(3):209-17. doi: 10.1136/oem.38.3.209.
Abstract
Plasma lead concentrations were determined in 103 subjects, including lead workers and those not occupationally exposed to lead. The plasma lead concentrations in each blood lead group were about half those previously reported, and this difference was shown to be due to the use of heparin instead of ethylenediaminetetra-acetic acid (EDTA) as the anticoagulant. The method for the determination of lead in plasma is detailed and its accuracy discussed. The plasma lead concentration was found to increase with the erythrocyte lead concentration, the mean equilibrium ratio between the two being about 0.74%. The effect of a sudden disturbance of the equilibrium condition on this ratio was investigated. This work supports the view that whole blood lead concentrations should be corrected for haematocrit.
摘要
对103名受试者的血浆铅浓度进行了测定，这些受试者包括铅作业工人和非职业性接触铅的人员。每个血铅组的血浆铅浓度约为先前报道值的一半，结果表明这种差异是由于使用肝素而非乙二胺四乙酸（EDTA）作为抗凝剂所致。详细介绍了血浆铅的测定方法并讨论了其准确性。发现血浆铅浓度随红细胞铅浓度升高而增加，二者的平均平衡比约为0.74%。研究了平衡条件突然受到干扰对该比例的影响。这项工作支持了全血铅浓度应根据血细胞比容进行校正的观点。
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