Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Bone. 2019 Jul;124:33-39. doi: 10.1016/j.bone.2019.03.034. Epub 2019 Mar 27.
Hydrogen sulfide (HS) has been known as a gasotransmitter, and it contributes to various physiological and pathological processes. Multiple enzymes such as cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous HS, and these are differentially expressed in the various tissue systems including the skeletal system. However, abnormal HS production is associated with deregulation of the signaling cascade and imbalanced tissue homeostasis. Several studies have previously provided evidence showing the essential regulatory action of HS in skeletal homeostasis. In this review, we have emphasized the novel function of HS in both bone and skeletal muscle anabolism, in particular. Additionally, we also reviewed the molecular and epigenetic basis of HS signaling in bone development and skeletal muscle function.
硫化氢 (HS) 作为一种气体递质而被人们熟知，它参与了多种生理和病理过程。多种酶，如半胱氨酸-β-合成酶 (CBS)、半胱氨酸-γ-裂解酶 (CSE) 和 3-巯基丙酮酸硫转移酶 (MST)，可产生内源性 HS，这些酶在包括骨骼系统在内的各种组织系统中呈现差异表达。然而，异常的 HS 产生与信号级联的失调和组织内稳态的失衡有关。之前的几项研究已经提供了证据，表明 HS 在骨骼内稳态中具有重要的调节作用。在这篇综述中，我们特别强调了 HS 在骨骼和骨骼肌合成代谢中的新功能。此外，我们还回顾了 HS 信号在骨骼发育和骨骼肌功能中的分子和表观遗传基础。
