Clyne L P
Blut. 1986 Oct;53(4):287-92. doi: 10.1007/BF00320886.
Mixing studies using activated partial thromboplastin time (APTT) technique were performed on 14 patients with lupus-like anticoagulants (LLACs) using human, equine, bovine, porcine and canine plasma. Eleven patients significantly prolonged the APTT of normal human plasma (patient/control ratio = greater than 1.15) but no patient inhibited bovine plasma. However, with one exception, equine APTT ratios were concordant with human ratios. Seven of fourteen patients also inhibited porcine plasma but in each case porcine APTT ratios were lower than their human or equine counterparts. None of five patients tested inhibited canine plasma. Collectively, these results suggest heterogeneity among LLACs at least with regard to species specificity.
采用活化部分凝血活酶时间（APTT）技术，使用人、马、牛、猪和犬血浆对14例狼疮抗凝物（LLAC）患者进行了混合试验研究。11例患者显著延长了正常人血浆的APTT（患者/对照比值大于1.15），但没有患者抑制牛血浆。然而，除1例例外，马APTT比值与人的比值一致。14例患者中有7例也抑制猪血浆，但在每种情况下，猪APTT比值均低于其对应的人或马的APTT比值。5例接受检测的患者均未抑制犬血浆。总体而言，这些结果表明LLAC之间至少在物种特异性方面存在异质性。
