线粒体接触位点的不断扩展和意想不到的功能。
The Expanding and Unexpected Functions of Mitochondria Contact Sites.
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
出版信息
Trends Cell Biol. 2019 Jul;29(7):580-590. doi: 10.1016/j.tcb.2019.02.009. Epub 2019 Mar 28.
Abstract
Mitochondria make functionally relevant contacts with most, if not all, other organelles in the cell. These contacts impact on mitochondrial behavior and function as well as on a wide variety of cellular functions. Many recent advances have been made in the rapidly growing field of mitochondria contact site biology, and these advances have expanded the known functions of mitochondria contact sites in exciting and unexpected ways.
摘要
线粒体与细胞中的大多数（如果不是全部）其他细胞器形成具有功能相关性的接触。这些接触不仅影响线粒体的行为和功能，还影响各种细胞功能。在快速发展的线粒体接触位点生物学领域取得了许多新的进展，这些进展以令人兴奋和意想不到的方式扩展了线粒体接触位点的已知功能。
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Mol Biol Cell. 2019 Mar 1;30(5):691-702. doi: 10.1091/mbc.E18-07-0466. Epub 2019 Jan 16.
2
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J Cell Biol. 2019 Feb 4;218(2):559-579. doi: 10.1083/jcb.201807097. Epub 2018 Dec 11.
3
Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.
Cell Metab. 2019 Apr 2;29(4):993-1002.e6. doi: 10.1016/j.cmet.2018.11.004. Epub 2018 Dec 6.
4
Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.
Cell. 2018 Nov 15;175(5):1430-1442.e17. doi: 10.1016/j.cell.2018.09.057. Epub 2018 Oct 25.
5
EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.
Cell. 2018 Nov 29;175(6):1507-1519.e16. doi: 10.1016/j.cell.2018.10.009. Epub 2018 Nov 8.
6
The machineries, regulation and cellular functions of mitochondrial calcium.
Nat Rev Mol Cell Biol. 2018 Nov;19(11):713-730. doi: 10.1038/s41580-018-0052-8.
7
PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog.
F1000Res. 2018 Jul 16;7:1088. doi: 10.12688/f1000research.15523.1. eCollection 2018.
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