Lin Chuan-Chao, Nfor Oswald Ndi, Su Chun-Lang, Hsu Shu-Yi, Tantoh Disline Manli, Liaw Yung-Po
Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung.
School of Medicine.
Medicine (Baltimore). 2020 Nov 13;99(46):e23299. doi: 10.1097/MD.0000000000023299.
Calcific tendinitis (CT) of the shoulder is a painful disorder usually identified in individuals aged 40 and 60 years. The estimated global prevalence of CT is 2.7% to 36%. We examined the association of hyperlipidemia and sex with CT of the shoulder using Taiwan Biobank (TWB) and the National Health Insurance Research Database (NHIRD).Data were available for 9903 TWB participants who were recruited between 2008 and 2015. We used multiple logistic regression analysis to estimate the odds ratios (OR) and 95% confidence intervals (CI) for CT of the shoulder.Overall, 1564 women, and 1491 men were identified with hyperlipidemia. Women, compared to men, had higher odds of CT of the shoulder (OR, 1.53; 95% CI, 1.08-2.16). Hyperlipidemia, compared to no hyperlipidemia, was associated with an increased risk of CT (OR, 1.40; 95% CI, 1.02-1.93). The test for interaction was significant for sex and hyperlipidemia (P = .006). After stratification, the odds ratio for CT was 1.95 (95% CI, 1.30-2.92) in women and 0.82 (95% CI, 0.48-1.39) in men, respectively. Compared to men with no hyperlipidemia, the odds ratio was 0.86 (95% CI, 0.53-1.38) for men with hyperlipidemia and 2.00 (95% CI, 1.29-3.10) for women with hyperlipidemia.Importantly, our findings indicated that the risk for CT of the shoulder was higher among Taiwanese women with hyperlipidemia. However, CT risk among their male counterparts with hyperlipidemia was not significant.
肩部钙化性肌腱炎（CT）是一种疼痛性疾病，通常在40至60岁的人群中发现。全球CT的估计患病率为2.7%至36%。我们使用台湾生物银行（TWB）和国民健康保险研究数据库（NHIRD）研究了高脂血症和性别与肩部CT的关联。
有9903名在2008年至2015年期间招募的TWB参与者的数据可供使用。我们使用多元逻辑回归分析来估计肩部CT的比值比（OR）和95%置信区间（CI）。
总体而言，1564名女性和1491名男性被确定患有高脂血症。与男性相比，女性患肩部CT的几率更高（OR，1.53；95%CI，1.08 - 2.16）。与无高脂血症相比，高脂血症与CT风险增加相关（OR，1.40；95%CI，1.02 - 1.93）。性别和高脂血症的交互作用检验具有显著性（P = 0.006）。分层后，女性CT的比值比为1.95（95%CI，1.30 - 2.92），男性为0.82（95%CI，0.48 - 1.39）。与无高脂血症的男性相比，高脂血症男性的比值比为0.86（95%CI，0.53 - 1.38），高脂血症女性的比值比为2.00（95%CI，1.29 - 3.10）。
重要的是，我们的研究结果表明，台湾高脂血症女性患肩部CT的风险更高。然而，高脂血症男性患CT的风险并不显著。
