Hubbe Hendrik, Mendes Eduardo, Boukany Pouyan E
Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629HZ Delft, The Netherlands.
Micromachines (Basel). 2019 Mar 29;10(4):225. doi: 10.3390/mi10040225.
Polymer nanowire-related research has shown considerable progress over the last decade. The wide variety of materials and the multitude of well-established chemical modifications have made polymer nanowires interesting as a functional part of a diagnostic biosensing device. This review provides an overview of relevant publications addressing the needs for a nanowire-based sensor for biomolecules. Working our way towards the detection methods itself, we review different nanowire fabrication methods and materials. Especially for an electrical signal read-out, the nanowire should persist in a single-wire configuration with well-defined positioning. Thus, the possibility of the alignment of nanowires is discussed. While some fabrication methods immanently yield an aligned single wire, other methods result in disordered structures and have to be manipulated into the desired configuration.
在过去十年中，聚合物纳米线相关研究取得了显著进展。各种各样的材料以及众多成熟的化学修饰方法，使聚合物纳米线成为诊断生物传感设备功能部件的有趣选择。本综述概述了相关出版物，这些出版物涉及对基于纳米线的生物分子传感器的需求。在探讨检测方法本身的过程中，我们回顾了不同的纳米线制造方法和材料。特别是对于电信号读出，纳米线应保持单根线配置且定位明确。因此，讨论了纳米线排列的可能性。虽然一些制造方法固有地会产生排列整齐的单根线，但其他方法会导致无序结构，必须将其加工成所需配置。
