CCR6 γδ T Cells Home to Skin Wounds and Restore Normal Wound Healing in CCR6-Deficient Mice.
作者信息
Anderson Leif S, Yu Sebastian, Rivara Kathryn R, Reynolds Mack B, Hernandez Alfredo A, Wu Xuesong, Yang Hsin-Ya, Isseroff Roslyn R, Miller Lloyd S, Hwang Sam T, Simon Scott I
机构信息
Department of Biomedical Engineering, University of California Davis, Davis, California, USA.
Department of Dermatology, University of California Davis, Sacramento, California, USA.
出版信息
J Invest Dermatol. 2019 Sep;139(9):2061-2064.e2. doi: 10.1016/j.jid.2019.02.032. Epub 2019 Mar 29.
Abstract
摘要
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Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A.γ4T 细胞通过白介素-17A 抑制树突状表皮 T 细胞的促愈功能，从而延缓皮肤伤口愈合。
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Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.通过 IL-1 依赖性激活 γδT 细胞来刺激毛囊干细胞增殖。
Elife. 2017 Dec 4;6:e28875. doi: 10.7554/eLife.28875.
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Vγ4 γδ T Cells Provide an Early Source of IL-17A and Accelerate Skin Graft Rejection.Vγ4 γδ T细胞是白细胞介素-17A的早期来源，并加速皮肤移植排斥反应。
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Defects in dermal Vγ4 γ δ T cells result in delayed wound healing in diabetic mice.真皮Vγ4 γδ T细胞缺陷导致糖尿病小鼠伤口愈合延迟。
Am J Transl Res. 2016 Jun 15;8(6):2667-80. eCollection 2016.
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IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.白细胞介素-17A促进皮肤中的嗜中性粒细胞炎症反应并干扰急性伤口愈合。
Exp Dermatol. 2017 Feb;26(2):137-144. doi: 10.1111/exd.13115. Epub 2016 Nov 16.
6
CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis.CCR6 对于 γδ-T 细胞在白细胞介素 23 诱导的银屑病样皮炎模型中的表皮转运是必需的。
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7
Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.鉴定新型炎症性人皮肤归巢 Vγ9Vδ2 T 细胞亚群，其在银屑病中可能具有潜在作用。
J Immunol. 2011 Sep 1;187(5):2783-93. doi: 10.4049/jimmunol.1100804. Epub 2011 Aug 3.
8
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A role for skin gammadelta T cells in wound repair.皮肤γδ T细胞在伤口修复中的作用。
Science. 2002 Apr 26;296(5568):747-9. doi: 10.1126/science.1069639.
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