Sun Hui, Zhu Xiaoshuai, Li Dan, Cheng Tao
1 Department of Stomatology, Chinese PLA General Hospital, Beijing, P. R. China.
2 Department of Thoracic Surgery, Shandong Weifang Yi Du Central Hospital, Weifang, P. R. China.
J Int Med Res. 2019 May;47(5):2126-2134. doi: 10.1177/0300060519831171. Epub 2019 Apr 2.
Both compound vitamin B mixtures and GeneTime® have been used in treatment of oral inflammation. This study aimed to assess the therapeutic effects of a compound vitamin B mixture combined with GeneTime® on radiation-induced oral mucositis.
A total of 100 patients with radiation-induced oral mucositis were randomly divided into a control group (vitamin B alone; n = 50 patients) and an observation group (vitamin B plus GeneTime®, n = 50 patients). Clinical outcomes were compared between the two groups for the following 3 weeks.
The observation group had a significantly greater number of grade 0-I patients and significantly fewer grade II-IV patients than the control group. Among patients in the observation group, a significantly greater number of ulcers healed within 1-2 weeks, compared with those in patients in the control group. Significantly fewer ulcers healed among patients in the observation group at 3 weeks; notably, there were fewer ulcers to heal in the observation group, compared with the control group.
Use of a compound vitamin B mixture combined with GeneTime® exerted obvious therapeutic effects on radiation-induced oral mucositis and markedly shortened ulcer healing time. Therefore, this strategy may be useful in clinical applications.
复合维生素B合剂和吉诺通均已用于口腔炎症的治疗。本研究旨在评估复合维生素B合剂联合吉诺通对放射性口腔黏膜炎的治疗效果。
将100例放射性口腔黏膜炎患者随机分为对照组（单纯维生素B；n = 50例患者）和观察组（维生素B加吉诺通，n = 50例患者）。在接下来的3周内比较两组的临床结局。
与对照组相比，观察组0-I级患者数量显著更多，II-IV级患者数量显著更少。在观察组患者中，与对照组患者相比，1-2周内愈合的溃疡数量显著更多。观察组患者在3周时愈合的溃疡显著更少；值得注意的是，与对照组相比，观察组需要愈合的溃疡更少。
复合维生素B合剂联合吉诺通对放射性口腔黏膜炎具有明显的治疗效果，并显著缩短了溃疡愈合时间。因此，该策略可能在临床应用中有用。
