Zhang Wei-Zheng, Peng Qi, Cai Xiang-Sheng, Jiang Gu-Li, Huang Jie-Jing, Lu Lan-Lan, Feng Wen-Zhuo, Yan Pei-Yu, Gu Jie-Ruo
Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, P.R. China.
State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, P.R. China.
Medicine (Baltimore). 2025 Jan 31;104(5):e41399. doi: 10.1097/MD.0000000000041399.
This study aimed to compare whether differences in lifestyle and dietary habits have an impact on hyperuricemia and to provide a reliable basis for the health management of citizens in our city. A total of 10,883 subjects who did not suffer from hyperuricemia, was anticipated in this study in 2018. After 2 years of follow-up, 7727 did not suffer from hyperuricemia and 3156 suffered from hyperuricemia. Dietary habits and lifestyle were collected by questionnaire. Multivariate logistic regression was used to identify the risk factors of hyperuricemia. For the analysis of the amount of change in uric acid (UA) before and after 2 years, t-tests and spearman correlation were used to explore the differences between the groups, and the trend effect of each variable on the amount of change in uric acid was analyzed by linear regression equations. The results showed that the prevalence of hyperuricemia varied by sex, high-fat food, smoked and fried food, milk and soy products, sugary drinks, sleep time, and the degree of smoking and drinking. Among them, infrequent consumption of milk and soy products, and short sleep time were risk factors for hyperuricemia, and men were more likely to have elevated uric acid levels after 2 years. It is recommended that people with hyperuricemia should actively limit their intake of fried foods, alcohol, and purine-rich foods, increase their intake of milk and soy foods, increase their sleep time, and seek to improve kidney and liver function.
本研究旨在比较生活方式和饮食习惯的差异是否对高尿酸血症有影响,并为我市市民的健康管理提供可靠依据。2018年本研究预计纳入10883名未患高尿酸血症的受试者。经过2年随访,7727人未患高尿酸血症,3156人患高尿酸血症。通过问卷调查收集饮食习惯和生活方式。采用多因素logistic回归分析确定高尿酸血症的危险因素。对于2年后尿酸(UA)变化量的分析,采用t检验和spearman相关性分析探索组间差异,并通过线性回归方程分析各变量对尿酸变化量的趋势效应。结果显示,高尿酸血症的患病率因性别、高脂食物、烟熏和油炸食品、牛奶和豆制品、含糖饮料、睡眠时间以及吸烟和饮酒程度而异。其中,很少食用牛奶和豆制品以及睡眠时间短是高尿酸血症的危险因素,且男性在2年后尿酸水平升高的可能性更大。建议高尿酸血症患者应积极限制油炸食品、酒精和富含嘌呤食物的摄入,增加牛奶和大豆类食物的摄入,增加睡眠时间,并寻求改善肝肾功。